Fallahi Gholam-Hossein, Moazzami Kasra, Tabatabaeiyan Maryam, Zamani Mohammad Mehdi, Asgar-Shirazi Masoumeh, Najafi Mehri, Motamed Farzaneh, Farahmand Fatemeh, Khodad Ahmad, Khatami Gholam-Reza, Rezaei Nima
Department of Pediatric Gastroenterology of Children's Medical Center Hospital, Tehran, Iran.
Acta Gastroenterol Belg. 2009 Apr-Jun;72(2):230-4.
Inflammatory bowel disease (IBD) is a group of disorders, including Crohn's disease (CD), ulcerative colitis (UC) and indeterminate colitis (IC). Small intestine and colon are primarily affected in this group of disorders.
This single center study was performed to define demographic features and clinical characteristics of Iranian pediatric patients with IBD.
Fifty nine patients with IBD, who have been referred to Children's Medical Center Hospital during a 10-year period, were investigated in this study. The data was gathered by interviewing the patients and their families, as well as reviewing their medical records.
Among 59 patients with IBD, 23 cases had UC and 19 cases had CD, while the remaining 17 cases had IC. Patients with UC were significantly younger at the time of diagnosis in comparison with patients with CD. The most common symptoms were abdominal pain, diarrhea, fever and growth failure. Hepatobiliary abnormalities and arthritis were common extra intestinal manifestations. The median Pediatric Crohn's Disease Activity Index was 42.5 (range 20-60), whereas the median Pediatric Ulcerative Colitis Activity Index was 40 (range 20-70). Seven of 23 UC (30.4%) had proctatis, while 16 (69.6%) had extensive colitis. In CD, 11 of 19 (57.9%) had involvement of terminal ileum and colon, while inflammation was limited to the colon in 8 cases (42.1%). The colonoscopic findings in the IC group were heterogeneous.
This study provides epidemiological data on pediatric patients with IBD, which could be useful for health care workers in prompt diagnosis and appropriate treatment of early onset IBD.
炎症性肠病（IBD）是一组疾病，包括克罗恩病（CD）、溃疡性结肠炎（UC）和未定型结肠炎（IC）。这组疾病主要影响小肠和结肠。
本单中心研究旨在确定伊朗儿科炎症性肠病患者的人口统计学特征和临床特征。
本研究调查了在10年期间转诊至儿童医学中心医院的59例炎症性肠病患者。通过访谈患者及其家属以及查阅他们的病历收集数据。
在59例炎症性肠病患者中，23例患有溃疡性结肠炎，19例患有克罗恩病，其余17例患有未定型结肠炎。与克罗恩病患者相比，溃疡性结肠炎患者诊断时年龄显著更小。最常见的症状是腹痛、腹泻、发热和生长发育迟缓。肝胆异常和关节炎是常见的肠外表现。儿童克罗恩病活动指数中位数为42.5（范围20 - 60），而儿童溃疡性结肠炎活动指数中位数为40（范围20 - 70）。23例溃疡性结肠炎患者中有7例（30.4%）患有直肠炎，16例（69.6%）患有广泛性结肠炎。在克罗恩病患者中，19例中有11例（57.9%）累及回肠末端和结肠，8例（42.1%）炎症局限于结肠。未定型结肠炎组的结肠镜检查结果具有异质性。
本研究提供了儿科炎症性肠病患者的流行病学数据，这可能有助于医护人员对早发性炎症性肠病进行及时诊断和适当治疗。
