Center for Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA.
Proteins. 2009;77 Suppl 9(Suppl 9):123-7. doi: 10.1002/prot.22501.
The performance of the protein structure prediction server pro-sp3-TASSER in CASP8 is described. Compared to CASP7, the major improvement in prediction is in the quality of input models to TASSER. These improvements are due to the PRO-SP(3) threading method, the improved quality of contact predictions provided by TASSER_2.0, multiple short TASSER simulations for building the full-length model, and the accuracy of model selection using the TASSER-QA quality assessment method. Finally, we analyze the overall performance and highlight some successful predictions of the pro-sp3-TASSER server.
描述了蛋白质结构预测服务器 pro-sp3-TASSER 在 CASP8 中的表现。与 CASP7 相比，对 TASSER 输入模型的质量进行了主要改进。这些改进归因于 PRO-SP(3) 线程方法、TASSER_2.0 提供的改进的接触预测质量、用于构建全长模型的多个短 TASSER 模拟以及使用 TASSER-QA 质量评估方法进行模型选择的准确性。最后，我们分析了整体性能并突出了 pro-sp3-TASSER 服务器的一些成功预测。
