一种用于靶向脑癌治疗的高性能纳米生物光催化剂。
A high-performance nanobio photocatalyst for targeted brain cancer therapy.
作者信息
Rozhkova Elena A, Ulasov Ilya, Lai Barry, Dimitrijevic Nada M, Lesniak Maciej S, Rajh Tijana
机构信息
The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA.
出版信息
Nano Lett. 2009 Sep;9(9):3337-42. doi: 10.1021/nl901610f.
Abstract
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.
摘要
我们报告了通过二羟基苯二价连接体与抗体共价连接的5纳米二氧化钛颗粒对胶质母细胞瘤细胞具有显著且特异性的光毒性。连接体的应用使纳米生物杂化物能够吸收太阳光谱的可见光部分。光毒性由活性氧（ROS）介导，ROS引发癌细胞的程序性死亡。同步加速器X射线荧光显微镜（XFM）被用于在亚微米尺度直接可视化纳米生物共轭物在单个脑癌细胞中的分布。
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