Daniels Jan-Peter, Kelly Steven, Wickstead Bill, Gull Keith
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
Biol Direct. 2009 Jul 29;4:24. doi: 10.1186/1745-6150-4-24.
The transcription machineries of Archaea and eukaryotes are similar in many aspects, but little is understood about archaeal chromatin and its role in transcription. Here, we describe the identification in hyperthermophilic Crenarchaeota and a Korarchaeon of an orthologue of the eukaryotic transcription elongation factor Elf1, which has been shown to function in chromatin structure maintenance of actively transcribed templates. Our discovery has implications for the relationship of chromatin and transcription in Archaea and the evolution of these processes in eukaryotes.
古菌和真核生物的转录机制在许多方面相似，但对于古菌染色质及其在转录中的作用却知之甚少。在此，我们描述了在嗜热泉古菌和泉古菌门中鉴定出真核生物转录延伸因子Elf1的一个直系同源物，该因子已被证明在活跃转录模板的染色质结构维持中发挥作用。我们的发现对古菌中染色质与转录的关系以及这些过程在真核生物中的进化具有启示意义。
