Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland.
Parkinsonism Relat Disord. 2010 Jan;16(1):31-5. doi: 10.1016/j.parkreldis.2009.06.005. Epub 2009 Jul 28.
Large population based studies on the association of Parkinson disease (PD) with stroke are scarce. This study aimed to quantify the risk of a first-time diagnosis of idiopathic PD in patients with a history of stroke, and to assess incidence rates for stroke in PD patients.
We used the UK-based General Practice Research Database to compare the prevalence of stroke/TIA in newly diagnosed PD patients and in a matched comparison group without PD between 1994 and 2005. We conducted a follow-up study with a nested case-control analysis to quantify the risk of incident stroke/TIA in relation to a previous PD diagnosis.
A history of stroke/TIA was associated with a significantly increased relative risk of being diagnosed with PD compared to patients without such a history (adj. odds ratio [OR] 1.65, 95% confidence intervals [CI] 1.47-2.00). In the cohort study, the crude incidence rate ratios (IRRs) for incident hemorrhagic stroke, ischemic stroke or TIA were 0.66 (95% CI 0.26-1.72), 1.46 (95% CI 1.03-2.07) and 1.86 (95% CI 1.40-2.47), respectively.
In this large observational study the risk of a PD diagnosis was significantly increased after a previous stroke event, as was the risk of a first-time ischemic stroke in newly diagnosed PD patients compared to persons free of PD.
关于帕金森病（PD）与中风之间关联的大规模基于人群的研究很少。本研究旨在量化有中风病史的患者首次诊断为特发性 PD 的风险，并评估 PD 患者中风的发病率。
我们使用基于英国的全科医生研究数据库，比较了 1994 年至 2005 年间新诊断为 PD 的患者和无 PD 的匹配对照组中风/TIA 的患病率。我们进行了一项随访研究，采用嵌套病例对照分析来量化与先前 PD 诊断相关的新发中风/TIA 的风险。
与无此类病史的患者相比，有中风/TIA 病史的患者被诊断为 PD 的相对风险显著增加（调整后的优势比 [OR] 1.65，95%置信区间 [CI] 1.47-2.00）。在队列研究中，新发出血性中风、缺血性中风或 TIA 的粗发病率比（IRR）分别为 0.66（95% CI 0.26-1.72）、1.46（95% CI 1.03-2.07）和 1.86（95% CI 1.40-2.47）。
在这项大型观察性研究中，与无 PD 的患者相比，先前中风事件后 PD 诊断的风险显著增加，新诊断为 PD 的患者首次发生缺血性中风的风险也增加。
