Lambert Stephen B, Faux Cassandra E, Hall Lisa, Birrell Frances A, Peterson Karen V, Selvey Christine E, Sloots Theo P, Nissen Michael D, Grimwood Keith
Queensland Paediatric Infectious Diseases Laboratory, Royal Children's Hospital, and Discipline of Paediatrics and Child Health, University of Queensland, Brisbane, QLD, Australia.
Med J Aust. 2009 Aug 3;191(3):157-60. doi: 10.5694/j.1326-5377.2009.tb02727.x.
To assess the impact of introducing a publicly funded infant rotavirus vaccination program on disease notifications and on laboratory testing and results.
Retrospective analysis of routinely collected data (rotavirus notifications [2006-2008] and laboratory rotavirus testing data from Queensland Health laboratories [2000-2008]) to monitor rotavirus trends before and after the introduction of a publicly funded infant rotavirus vaccination program in Queensland in July 2007.
Age group-specific rotavirus notification trends; number of rotavirus tests performed and the proportion positive.
In the less than 2 years age group, rotavirus notifications declined by 53% (2007) and 65% (2008); the number of laboratory tests performed declined by 3% (2007) and 15% (2008); and the proportion of tests positive declined by 45% (2007) and 43% (2008) compared with data collected before introduction of the vaccination program. An indirect effect of infant vaccination was seen: notifications and the proportion of tests positive for rotavirus declined in older age groups as well.
The publicly funded rotavirus vaccination program in Queensland is having an early impact, direct and indirect, on rotavirus disease as assessed using routinely collected data. Further observational studies are required to assess vaccine effectiveness. Parents and immunisation providers should ensure that all Australian children receive the recommended rotavirus vaccine doses in the required timeframe.
评估引入公共资助的婴儿轮状病毒疫苗接种计划对疾病报告以及实验室检测和结果的影响。
对常规收集的数据（2006 - 2008年的轮状病毒报告以及昆士兰卫生实验室2000 - 2008年的轮状病毒实验室检测数据）进行回顾性分析，以监测2007年7月昆士兰引入公共资助的婴儿轮状病毒疫苗接种计划前后的轮状病毒趋势。
特定年龄组的轮状病毒报告趋势；进行的轮状病毒检测数量及阳性比例。
在2岁以下年龄组，与疫苗接种计划引入前收集的数据相比，轮状病毒报告在2007年下降了53%，在2008年下降了65%；进行的实验室检测数量在2007年下降了3%，在2008年下降了15%；检测阳性比例在2007年下降了45%，在2008年下降了43%。观察到婴儿接种疫苗的间接影响：在年龄较大的组中，轮状病毒报告和检测阳性比例也有所下降。
昆士兰的公共资助轮状病毒疫苗接种计划正在对轮状病毒疾病产生早期的直接和间接影响，这是通过常规收集的数据评估得出的。需要进一步的观察性研究来评估疫苗的有效性。家长和免疫接种提供者应确保所有澳大利亚儿童在规定时间内接种推荐剂量的轮状病毒疫苗。
