Munday J S, Dunowska M, De Grey S
Department of Pathobiology, Insitutite of Veterinary, Animal and Biodmedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.
N Z Vet J. 2009 Aug;57(4):248-51. doi: 10.1080/00480169.2009.36911.
A 15-year-old, brown-and-white cat was presented to a veterinary clinic with an ulcerated, reddened 1-cm diameter lesion on the nasal planum.
Histology of a biopsy sample confirmed the lesion was a squamous cell carcinoma (SCC). PCR amplified DNA sequences from two different papillomaviruses. One sequence was from FdPV-2, which has previously been amplified from feline cutaneous SCC. However, the other sequence has not previously been reported, suggesting a novel feline papillomavirus.
There is evidence that papillomaviruses promote the development of SCC on sun-exposed skin in humans. This is the first report in a cat of a papillomavirus other than FdPV-2 and the first time that multiple papillomaviruses have been detected within a single neoplasm in this species. Whether the papillomaviruses influenced the development and behaviour of this SCC is currently uncertain, but this case provides additional evidence of the association between papillomaviruses and feline cutaneous SCC. If papillomaviruses are found to influence the development of SCC this may allow novel strategies to prevent these common neoplasms in cats.
一只15岁的棕白相间的猫被送到一家兽医诊所，其鼻平面上有一个直径1厘米的溃疡、发红的病变。
活检样本的组织学检查证实该病变为鳞状细胞癌（SCC）。聚合酶链反应（PCR）扩增出了来自两种不同乳头瘤病毒的DNA序列。其中一个序列来自FdPV - 2，该病毒此前已从猫皮肤鳞状细胞癌中扩增得到。然而，另一个序列此前尚未见报道，提示这是一种新型猫乳头瘤病毒。
有证据表明乳头瘤病毒会促进人类暴露于阳光下皮肤的鳞状细胞癌的发生。这是关于猫体内除FdPV - 2之外的乳头瘤病毒的首次报道，也是首次在该物种的单个肿瘤内检测到多种乳头瘤病毒。目前尚不确定这些乳头瘤病毒是否影响了该鳞状细胞癌的发生和行为，但此病例为乳头瘤病毒与猫皮肤鳞状细胞癌之间的关联提供了更多证据。如果发现乳头瘤病毒会影响鳞状细胞癌的发生，这可能会为预防猫的这些常见肿瘤提供新策略。
