Munday John S, Witham Adrian I
Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
Vet Dermatol. 2010 Jun;21(3):307-10. doi: 10.1111/j.1365-3164.2009.00811.x. Epub 2009 Dec 23.
Feline cutaneous squamous cell carcinomas (SCCs) often contain felis domesticus papillomavirus type 2 (FdPV-2) DNA. While this may suggest FdPV-2 causes feline SCC development, the proportion of cats that are asymptomatically infected by this PV is unknown. Infection by feline immunodeficiency virus (FIV) is associated with high rates of cutaneous SCC development, possibly due to increased PV infection. This study examines the frequency of cutaneous asymptomatic FdPV-2 infections in cats and compares the rate of FdPV-2 infection in 22 FIV-positive cats with that in 22 FIV-negative cats. FdPV-2 sequences were detected in 39% of skin swabs. One or both swabs contained FdPV-2 DNA from 52% of the cats. FIV status, age or sex of the cat did not significantly influence FdPV-2 infection. Cats that shared a household with a PV-infected cat could remain uninfected suggesting infection depends more on host factors than exposure to the PV. These results indicate that asymptomatic FdPV-2 infections are common in cats, but do not provide evidence that FdPV-2 causes feline SCC development.
猫皮肤鳞状细胞癌（SCCs）常含有家猫乳头瘤病毒2型（FdPV - 2）DNA。虽然这可能表明FdPV - 2会引发猫SCC的发展，但该乳头瘤病毒无症状感染猫的比例尚不清楚。猫免疫缺陷病毒（FIV）感染与皮肤SCC的高发有关，这可能是由于乳头瘤病毒感染增加所致。本研究调查了猫皮肤无症状FdPV - 2感染的频率，并比较了22只FIV阳性猫和22只FIV阴性猫的FdPV - 2感染率。在39%的皮肤拭子中检测到FdPV - 2序列。52%的猫的一个或两个拭子中含有FdPV - 2 DNA。猫的FIV状态、年龄或性别对FdPV - 2感染没有显著影响。与感染乳头瘤病毒的猫共居一室的猫可能不会被感染，这表明感染更多地取决于宿主因素而非接触乳头瘤病毒。这些结果表明，无症状FdPV - 2感染在猫中很常见，但没有提供证据表明FdPV - 2会引发猫SCC的发展。
