Chiudzu Grace, Choko Augustine T, Maluwa Alfred, Huber Sandra, Odland Jon
Department of Obstetrics and Gynecology, College of Medicine, University of Malawi, P.O. Box 30055, Lilongwe, Malawi.
TB/HIV Department, Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
J Pregnancy. 2020 Apr 30;2020:9435972. doi: 10.1155/2020/9435972. eCollection 2020.
Preterm birth is delivery before 37 completed weeks. A study was conducted to evaluate the association of maternal serum concentrations of selenium, copper, and zinc and preterm birth. There were 181 women in this nested case-control study, 90/181 (49.7%) term and 91/181 (50.3%) preterm pregnant women. The overall mean serum concentration of selenium was 77.0, SD 19.4 g/L; of copper was 2.50, SD 0.52 mg/L; and of zinc was 0.77, SD 0.20 mg/L with reference values of 47-142 g/L, 0.76-1.59 mg/L, and 0.59-1.11 mg/L, respectively. For preterm birth, mean serum concentration for selenium was 79.7, SD 21.6 g/L; for copper was 2.61, SD 0.57 mg/L; and for zinc was 0.81, SD 0.20 mg/L compared to that for term births: selenium (74.2; SD 16.5 g/L; = 0.058), copper (2.39; SD 0.43 mg/L; = 0.004), and zinc (0.73; SD 0.19 mg/L; = 0.006), respectively. In an adjusted analysis, every unit increase in maternal selenium concentrations gave increased odds of being a case OR 1.01 (95% CI: 0.99; 1.03), = 0.234; copper OR 1.62 (95% CI: 0.80; 3.32), = 0.184; zinc OR 6.88 (95% CI: 1.25; 43.67), = 0.032. Results show that there was no deficiency of selenium and zinc and there were high serum concentrations of copper in pregnancy. Preterm birth was associated with higher maternal serum concentrations of copper and zinc.
早产是指在妊娠满37周前分娩。一项研究旨在评估孕妇血清中硒、铜和锌的浓度与早产之间的关联。在这项巢式病例对照研究中有181名女性，其中90/181（49.7%）为足月孕妇，91/181（50.3%）为早产孕妇。血清硒的总体平均浓度为77.0，标准差为19.4μg/L；铜为2.50，标准差为0.52mg/L；锌为0.77，标准差为0.20mg/L，参考值分别为47 - 142μg/L、0.76 - 1.59mg/L和0.59 - 1.11mg/L。对于早产，血清硒的平均浓度为79.7，标准差为21.6μg/L；铜为2.61，标准差为0.57mg/L；锌为0.81，标准差为0.20mg/L，而足月产的相应数值分别为：硒（74.2；标准差16.5μg/L；P = 0.058）、铜（2.39；标准差0.43mg/L；P = 0.004）和锌（0.73；标准差0.19mg/L；P = 0.006）。在一项校正分析中，孕妇血清硒浓度每升高一个单位，成为病例的几率增加OR 1.01（95%可信区间：0.99；1.03），P = 0.234；铜OR 1.62（95%可信区间：0.80；3.32），P = 0.184；锌OR 6.88（95%可信区间：1.25；43.67），P = 0.032。结果表明，孕期不存在硒和锌缺乏，且血清铜浓度较高。早产与孕妇血清中较高的铜和锌浓度相关。
