Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departamento de Genética, Universitat de València, 46071 València, Spain.
Genetics. 2009 Oct;183(2):747-9. doi: 10.1534/genetics.109.106005. Epub 2009 Aug 3.
The point mutation rate of phage PhiX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0x10(-6) substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying in DNA-based microorganisms).
噬菌体 PhiX174 的点突变率是通过波动试验确定的。在确定与所选表型相关的遗传变化后，我们估计每个复制循环每个碱基的替换率为 1.0x10(-6)，这与德雷克规则（基于 DNA 的微生物中每个复制循环每个基因组 0.003 个突变）一致。
