Daubert G Patrick, Spiller Henry, Crouch Barbara Insley, Seifert Steven, Simone Karen, Smolinske Susan
Department of Emergency Medicine, University of California, Davis, Medical Center, Sacramento Division, California Poison Control System, Sacramento, California 59817, USA.
J Med Toxicol. 2009 Sep;5(3):125-9. doi: 10.1007/BF03161222.
We report a large number of cases of pulmonary toxicity from 6 regional poison control centers associated with the use of a waterproofing-grout sealer. The identification of this illness occurred by means of the poison control center (PCC) national automated toxicosurveillance.
This is a retrospective case review of all cases of pulmonary toxicity following exposure to a waterproofing grout sealer from 6 regional PCCs including Michigan, Kentucky, Utah, Maine, Arizona, and Nebraska. The study period extended from June 1, 2005 to December 1, 2005.
The vast majority of patients used the product at home (80%). Over half the patients presented within 3 hours of exposure. The most common presenting symptoms were shortness of breath (63%), cough (60%), and chest pain (44%). Wheezing (33%) and rales (23%) were the most common signs of clinical toxicity. One patient required endotracheal intubation. Thirty-seven percent of patients had signs of acute pneumonitis on initial chest x-ray. The mean presenting oxygen saturation was 89.5%. The most common treatment measures used were supplemental oxygen, bronchodilator therapy, oral steroids, and antibiotics. Over half of the study group required hospital admission.
The majority of patients in this study were adults using the product at home. Over one-third of patients had an abnormal x-ray upon presentation. Over half of the study group required hospital admission following exposure to this product. Medical professionals should be aware of the potential for pulmonary toxicity due to waterproofing aerosols.
我们报告了来自6个地区毒物控制中心的大量与使用防水填缝密封剂相关的肺部中毒病例。这种疾病是通过毒物控制中心（PCC）的全国自动毒物监测系统识别出来的。
这是一项对来自密歇根州、肯塔基州、犹他州、缅因州、亚利桑那州和内布拉斯加州6个地区PCC的所有接触防水填缝密封剂后发生肺部中毒病例的回顾性病例研究。研究时间段为2005年6月1日至2005年12月1日。
绝大多数患者在家中使用该产品（80%）。超过一半的患者在接触后3小时内就诊。最常见的症状是呼吸急促（63%）、咳嗽（60%）和胸痛（44%）。喘息（33%）和啰音（23%）是临床中毒最常见的体征。1名患者需要气管插管。37%的患者在初次胸部X光检查时有急性肺炎的体征。就诊时平均血氧饱和度为89.5%。最常用的治疗措施是吸氧、支气管扩张剂治疗、口服类固醇和抗生素。超过一半的研究组患者需要住院治疗。
本研究中的大多数患者是在家中使用该产品的成年人。超过三分之一的患者就诊时X光检查异常。超过一半的研究组患者接触该产品后需要住院治疗。医学专业人员应意识到防水气雾剂导致肺部中毒的可能性。
