Day Rachael C, Bradberry Sally M, Sandilands Euan A, Thomas Simon H L, Thompson John P, Vale J Allister
a NPIS (Birmingham Unit) , City Hospital , Birmingham , UK.
b NPIS (Edinburgh Unit) , Royal Infirmary , Edinburgh , UK.
Clin Toxicol (Phila). 2017 Aug;55(7):645-651. doi: 10.1080/15563650.2017.1306070. Epub 2017 Apr 26.
Oven cleaning products contain corrosive substances, typically sodium or potassium hydroxide.
To determine the reported toxicity from exposure to oven cleaning products.
Telephone enquiries to the UK National Poisons Information Service regarding oven cleaning products were analysed retrospectively for the period January 2009 to December 2015.
There were 796 enquiries relating to 780 patients. Ninety-six percent of the products involved in the reported exposures contained sodium hydroxide and/or potassium hydroxide. Ingestion alone (n = 285) or skin contact alone (n = 208) accounted for the majority of cases; inhalation alone (n = 101), eye contact alone (n = 97), and multiple routes of exposure (n = 89) accounted for the remainder. Ninety-five percent of patients exposed by inhalation, 94% exposed dermally and 85% reporting eye exposure, developed features of toxicity. Patients exposed by multiple routes developed symptoms in 70% of cases. Only 103 of the 285 patients ingested oven cleaner directly, whereas 182 patients ingested food they considered to have been contaminated with oven cleaner. In 100 of the 103 direct ingestions where the features and World Health Organisation/International Programme on Chemical Safety/European Commission/European Association of Poison Centres and Clinical Toxicologists Poisoning Severity Score were known, 56 reported symptoms which were minor in 51 cases. The most common features following ingestion were vomiting (n = 26), abdominal pain (n = 22) or pharyngitis (n = 15). Skin burns (n = 91) predominantly involving the hands or arms, occurred in 44% of dermal exposures. Following inhalation, patients frequently developed respiratory features (n = 52) including coughing and chest pain/tightness. Eye pain (n = 43) and conjunctivitis (n = 33) commonly occurred following ocular exposure.
Most (71%) patients exposed to an oven cleaner irrespective of the route of exposure developed features of toxicity, though in most cases only minor features developed; moderate or severe features ensued in ∼4%. Those patients exposed dermally, ophthalmically or by inhalation developed features more frequently (≥85%) than those who ingested a product directly (56%).
烤箱清洁产品含有腐蚀性物质,通常为氢氧化钠或氢氧化钾。
确定报告的接触烤箱清洁产品后的毒性情况。
对2009年1月至2015年12月期间向英国国家毒物信息服务中心就烤箱清洁产品进行的电话咨询进行回顾性分析。
有796次咨询涉及780名患者。报告的接触事件中,96%的产品含有氢氧化钠和/或氢氧化钾。仅摄入(n = 285)或仅皮肤接触(n = 208)占大多数病例;仅吸入(n = 101)、仅眼部接触(n = 97)以及多种接触途径(n = 89)占其余病例。95%的吸入接触患者、94%的皮肤接触患者和85%报告眼部接触的患者出现了中毒症状。多种途径接触的患者中,70%出现了症状。285名摄入烤箱清洁剂的患者中,只有103人直接摄入,而182名患者摄入了他们认为被烤箱清洁剂污染的食物。在已知特征和世界卫生组织/国际化学品安全规划署/欧盟委员会/欧洲毒物中心和临床毒理学家协会中毒严重程度评分的103例直接摄入病例中,56例报告有症状,其中51例症状较轻。摄入后最常见的症状是呕吐(n = 26)、腹痛(n = 22)或咽炎(n = 15)。皮肤烧伤(n = 91)主要累及手部或手臂,发生在44%的皮肤接触病例中。吸入后,患者经常出现呼吸道症状(n = 52),包括咳嗽和胸痛/胸闷。眼部接触后常见眼痛(n = 43)和结膜炎(n = 33)。
大多数(71%)接触烤箱清洁剂的患者,无论接触途径如何,都出现了中毒症状,不过在大多数情况下仅出现轻微症状;约4%出现中度或重度症状。那些通过皮肤、眼部或吸入接触的患者比直接摄入产品的患者更频繁地出现症状(≥85%对56%)。