Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA.
Neural Netw. 2009 Oct;22(8):1129-38. doi: 10.1016/j.neunet.2009.07.012. Epub 2009 Jul 18.
Neurophysiological data reveals intrinsic cellular properties that suggest how entorhinal cortical neurons could code memory by the phase of their firing. Potential cellular mechanisms for this phase coding in models of entorhinal function are reviewed. This mechanism for phase coding provides a substrate for modeling the responses of entorhinal grid cells, as well as the replay of neural spiking activity during waking and sleep. Efforts to implement these abstract models in more detailed biophysical compartmental simulations raise specific issues that could be addressed in larger scale population models incorporating mechanisms of inhibition.
神经生理数据揭示了内在的细胞特性，表明了内嗅皮层神经元如何通过其放电的相位来编码记忆。本文回顾了内嗅功能模型中这种相位编码的潜在细胞机制。这种相位编码机制为模拟内嗅网格细胞的反应以及在清醒和睡眠期间神经尖峰活动的回放提供了基础。在更详细的生物物理室分模拟中实现这些抽象模型的努力提出了一些具体问题，这些问题可以在包含抑制机制的更大规模群体模型中得到解决。
