• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠脑内质网钙池在解剖学和功能上是分隔的。

Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.

作者信息

Verma A, Ross C A, Verma D, Supattapone S, Snyder S H

机构信息

Johns Hopkins University School of Public Health, Department of Toxicology, Baltimore, Maryland 21205.

出版信息

Cell Regul. 1990 Sep;1(10):781-90. doi: 10.1091/mbc.1.10.781.

DOI:10.1091/mbc.1.10.781
PMID:1966012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361662/
Abstract

Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+, Mg2(+)-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+, Mg2(+)-ATPase. Inositol 1,4,5-triphosphate [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+, -Mg2(+)-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.

摘要

放射自显影成像能够定位通过Ca2+、Mg2(+)-ATP酶选择性积累到大鼠脑切片内质网储存库中的45Ca2+。草酸盐能显著刺激45Ca2+的积累，且呈现出一种异质性分布，这种分布类似于肌质网Ca2+、Mg2(+)-ATP酶的mRNA分布。肌醇1,4,5-三磷酸[I(1,4,5)P3]选择性抑制45Ca2+积累到与富含I(1,4,5)P3受体结合位点及Ca2+、Mg2(+)-ATP酶mRNA的区域相对应的部位。因此，大鼠脑内质网钙储存库在解剖学和功能上是有差异的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/83296e532c55/cellregul00047-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/ef05f38133d6/cellregul00047-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/d106d3df3373/cellregul00047-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/4a2770e0d7fa/cellregul00047-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/83296e532c55/cellregul00047-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/ef05f38133d6/cellregul00047-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/d106d3df3373/cellregul00047-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/4a2770e0d7fa/cellregul00047-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf9/361662/83296e532c55/cellregul00047-0076-a.jpg

相似文献

1
Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.大鼠脑内质网钙池在解剖学和功能上是分隔的。
Cell Regul. 1990 Sep;1(10):781-90. doi: 10.1091/mbc.1.10.781.
2
Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin.浦肯野神经元中的钙离子储存：通过肌醇三磷酸受体、钙ATP酶和肌集钙蛋白的异质性分布所显示的内质网亚区室
J Neurosci. 1992 Feb;12(2):489-505. doi: 10.1523/JNEUROSCI.12-02-00489.1992.
3
Intracellular Ca2+ stores of rat cerebellum: heterogeneity within and distinction from endoplasmic reticulum.大鼠小脑的细胞内钙储存：内质网内的异质性及其与内质网的区别
Biochem J. 1993 Apr 1;291 ( Pt 1)(Pt 1):199-204. doi: 10.1042/bj2910199.
4
Subcellular distribution of the calcium-storing inositol 1,4,5-trisphosphate-sensitive organelle in rat liver. Possible linkage to the plasma membrane through the actin microfilaments.大鼠肝脏中储存钙的1,4,5-三磷酸肌醇敏感细胞器的亚细胞分布。通过肌动蛋白微丝与质膜的可能联系。
Biochem J. 1991 Mar 15;274 ( Pt 3)(Pt 3):643-50. doi: 10.1042/bj2740643.
5
Localization of an endoplasmic reticulum calcium ATPase mRNA in rat brain by in situ hybridization.
Neuroscience. 1991;43(1):1-9. doi: 10.1016/0306-4522(91)90410-p.
6
Neuronal endoplasmic reticulum acts as a single functional Ca2+ store shared by ryanodine and inositol-1,4,5-trisphosphate receptors as revealed by intra-ER [Ca2+] recordings in single rat sensory neurones.通过对单个大鼠感觉神经元内质网内[Ca2+]的记录发现，神经元内质网作为一个由兰尼碱受体和肌醇-1,4,5-三磷酸受体共享的单一功能性Ca2+储存库。
Pflugers Arch. 2003 Jul;446(4):447-54. doi: 10.1007/s00424-003-1094-z. Epub 2003 May 23.
7
Inositol trisphosphate analogues selective for types I and II inositol trisphosphate receptors exert differential effects on vasopressin-stimulated Ca2+ inflow and Ca2+ release from intracellular stores in rat hepatocytes.对I型和II型肌醇三磷酸受体具有选择性的肌醇三磷酸类似物，对大鼠肝细胞中血管加压素刺激的Ca2+内流以及细胞内储存的Ca2+释放具有不同的影响。
Biochem J. 2004 Jul 15;381(Pt 2):519-26. doi: 10.1042/BJ20040637.
8
Relationship between calcium ion transport and (Ca2+ + Mg2+)-atpase activity in adipocyte endoplasmic reticulum.脂肪细胞内质网中钙离子转运与（Ca2+ + Mg2+）-ATP酶活性之间的关系
Biochim Biophys Acta. 1980 Mar 13;596(3):359-71. doi: 10.1016/0005-2736(80)90123-6.
9
Luminal Ca2+ protects against thapsigargin inhibition in neuronal endoplasmic reticulum.
J Biol Chem. 1998 Feb 27;273(9):5020-5. doi: 10.1074/jbc.273.9.5020.
10
Selective inhibition of inositol 1,4,5-triphosphate-induced Ca2+ release in the CA1 region of the hippocampus in the ischemic gerbil.
Neuroscience. 1999;93(3):995-1001. doi: 10.1016/s0306-4522(99)00198-0.

引用本文的文献

1
Glucose-6-phosphate reduces calcium accumulation in rat brain endoplasmic reticulum.葡萄糖-6-磷酸可减少大鼠脑内质网钙积累。
Front Mol Neurosci. 2012 Apr 20;5:51. doi: 10.3389/fnmol.2012.00051. eCollection 2012.
2
Subcellular distribution of Homer 1b/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons.浦肯野神经元中Homer 1b/c与内质网和质膜蛋白相关的亚细胞分布。
Neurochem Res. 2003 Aug;28(8):1151-8. doi: 10.1023/a:1024264025401.
3
Intracellular Ca2+ stores of rat cerebellum: heterogeneity within and distinction from endoplasmic reticulum.

本文引用的文献

1
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells.三磷酸肌醇诱导通透化的瑞士小鼠3T3细胞释放钙的特异性
Biochem J. 1984 Aug 15;222(1):269-72. doi: 10.1042/bj2220269.
2
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.膜磷酸肌醇在激动剂依赖性水解后肌醇磷酸水平的变化。
Biochem J. 1983 May 15;212(2):473-82. doi: 10.1042/bj2120473.
3
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
大鼠小脑的细胞内钙储存：内质网内的异质性及其与内质网的区别
Biochem J. 1993 Apr 1;291 ( Pt 1)(Pt 1):199-204. doi: 10.1042/bj2910199.
4
Expression of the calsequestrin gene in chicken cerebellum Purkinje neurons.鸡小脑浦肯野神经元中肌集钙蛋白基因的表达
Biochem J. 1993 Sep 1;294 ( Pt 2)(Pt 2):487-90. doi: 10.1042/bj2940487.
5
The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.兰尼碱受体/钙通道基因在小鼠脑和外周组织中广泛且差异表达。
J Cell Biol. 1995 Mar;128(5):893-904. doi: 10.1083/jcb.128.5.893.
6
Calcium pools mobilized by calcium or inositol 1,4,5-trisphosphate are differentially localized in rat heart and brain.由钙或肌醇1,4,5-三磷酸动员的钙池在大鼠心脏和大脑中的定位不同。
Mol Biol Cell. 1992 Jun;3(6):621-31. doi: 10.1091/mbc.3.6.621.
抗生物素蛋白-生物素-过氧化物酶复合物（ABC）在免疫过氧化物酶技术中的应用：ABC法与未标记抗体（PAP）法的比较。
J Histochem Cytochem. 1981 Apr;29(4):577-80. doi: 10.1177/29.4.6166661.
4
Functional importance of the synaptic plasma membrane calcium pump and sodium-calcium exchanger.突触质膜钙泵和钠钙交换器的功能重要性。
J Biol Chem. 1984 Sep 10;259(17):10807-13.
5
Vasopressin and oxytocin mRNAs in adrenalectomized and Brattleboro rats: analysis by quantitative in situ hybridization histochemistry.去肾上腺大鼠和布拉特洛伐大鼠中血管加压素和催产素mRNA：通过定量原位杂交组织化学进行分析
Brain Res. 1986 Dec;387(3):231-41. doi: 10.1016/0169-328x(86)90029-x.
6
Inositol 1,4,5-trisphosphate and 5'-GTP induce calcium release from different intracellular pools.肌醇1,4,5-三磷酸和5'-鸟苷三磷酸从不同的细胞内池诱导钙释放。
FEBS Lett. 1987 Jun 22;218(1):153-8. doi: 10.1016/0014-5793(87)81037-2.
7
Guanosine 5'-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1,4,5-trisphosphate.
FEBS Lett. 1986 Jul 7;202(2):267-73. doi: 10.1016/0014-5793(86)80699-8.
8
Inositol trisphosphate and diacylglycerol: two interacting second messengers.肌醇三磷酸和二酰甘油：两种相互作用的第二信使。
Annu Rev Biochem. 1987;56:159-93. doi: 10.1146/annurev.bi.56.070187.001111.
9
Characterization of inositol 1,4,5-trisphosphate-stimulated calcium release from rat cerebellar microsomal fractions. Comparison with [3H]inositol 1,4,5-trisphosphate binding.大鼠小脑微粒体组分中肌醇1,4,5-三磷酸刺激的钙释放的特性。与[3H]肌醇1,4,5-三磷酸结合的比较。
Biochem J. 1988 Oct 15;255(2):677-83.
10
Persistent inhibition by inositol 1,4,5-trisphosphate of oxalate-dependent 45calcium accumulation in permeable guinea-pig hepatocytes.
Cell Calcium. 1988 Feb;9(1):9-16. doi: 10.1016/0143-4160(88)90033-4.