Calderon-Arnulphi Mateo, Alaraj Ali, Slavin Konstantin V
Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL 60612, USA.
Neurol Res. 2009 Jul;31(6):605-14. doi: 10.1179/174313209X383286.
To review past, present and future applications of near-infrared spectroscopy (NIRS) in clinical neuroscience.
The literature and personal experience of the authors were critically reviewed in order to provide a balanced overview of the basic principles, clinical validation, previous experience and current use of NIRS in assessment of cerebral oxygenation in clinical neuroscience.
Recent technological advancements in transcranial cerebral oximetry (TCCO) are opening up a new promising avenue in clinical neuroscience. With its non-invasive nature, high reliability and uniqueness of gathered data, NIRS represents a very special modality in the neuroscience intensive care unit, angiography suite and the operating room. The hurdles of using this technology in clinical practice are discussed in detail. In addition, we evaluate some known limitations of NIRS and current controversies around its use. Lastly, several commercially available cerebral oximeters are presented.
Despite remarkable developments in the NIRS technology and proven reliability of the cerebral oxygenation monitoring approach, TCCO remains mostly an adjuvant tool for neuroscience applications. Newer NIRS technologies have become a source of quantitative information about brain oxygenation, cerebral blood volume and flow. However, the clinical significance of this new information in the context of clinical neuroscience will need to be determined and further validation studies will need to be performed.
回顾近红外光谱技术（NIRS）在临床神经科学领域过去、现在及未来的应用情况。
对作者的文献及个人经验进行严格审查，以便全面、平衡地概述NIRS在临床神经科学中评估脑氧合的基本原理、临床验证、既往经验及当前应用情况。
经颅脑氧饱和度测定技术（TCCO）的最新技术进展为临床神经科学开辟了一条充满希望的新途径。由于其具有非侵入性、高可靠性以及所采集数据的独特性，NIRS在神经科学重症监护病房、血管造影室及手术室中代表着一种非常特殊的方式。详细讨论了在临床实践中使用该技术所面临的障碍。此外，我们评估了NIRS的一些已知局限性以及围绕其使用的当前争议。最后，介绍了几种市面上可买到的脑氧饱和度仪。
尽管NIRS技术取得了显著进展，且脑氧合监测方法已被证明具有可靠性，但TCCO在神经科学应用中大多仍为辅助工具。更新的NIRS技术已成为获取有关脑氧合、脑血容量和血流的定量信息的来源。然而，这种新信息在临床神经科学背景下的临床意义仍有待确定，还需要进行进一步的验证研究。
