Department of Neonatology, La Paz University Hospital, Paseo de la Castellana 261, E-28046 Madrid, Spain.
Semin Fetal Neonatal Med. 2011 Feb;16(1):42-9. doi: 10.1016/j.siny.2010.05.003. Epub 2010 Jun 26.
Near infrared spectroscopy (NIRS) is a light-based technology used to monitor tissue oxygen status. Refinements to the method since it was first described have extended its applicability to different research and clinical settings due to its non-invasiveness, instrument portability and ease of use. Classic NIRS recordings, based in the Beer-Lambert law, can be used for the trend monitoring of changes in tissue perfusion-oxygenation parting from an arbitrary zero point. However, in order to derive intermittently quantitative values in absolute terms, certain manoeuvres must be performed. More recently, the evolution of the technique has led to the development of instruments that provide an absolute value of regional hemoglobin saturation in a continuous manner. This review will focus on the physical principles of tissue spectroscopy including a brief description of the different operating principles that are currently in use or under development. The theoretical details, experimental procedures and data analysis involved in the measurements of physiological variables using NIRS will be described. The future beyond the scope of NIRS and potential lines of research will also be discussed.
近红外光谱（NIRS）是一种基于光的技术，用于监测组织氧合状态。自从首次描述以来，该方法的改进扩展了其在不同研究和临床环境中的适用性，因为它具有非侵入性、仪器便携性和易用性。基于 Beer-Lambert 定律的经典 NIRS 记录可用于从任意零点开始监测组织灌注-氧合变化的趋势。然而，为了以绝对值获得间歇定量值，必须执行某些操作。最近，该技术的发展导致了开发出能够连续提供区域血红蛋白饱和度绝对值的仪器。本综述将重点介绍组织光谱学的物理原理，包括对当前使用或正在开发的不同工作原理的简要描述。将描述使用 NIRS 测量生理变量所涉及的理论细节、实验程序和数据分析。还将讨论 NIRS 范围之外的未来和潜在的研究方向。
