高乌甲素凝胶剂的镇痛抗炎作用研究
Study of analgesic and anti-inflammatory effects of lappaconitine gelata.
作者信息
Wang Ying-zi, Xiao Yong-qing, Zhang Chao, Sun Xiu-mei
机构信息
College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
出版信息
J Tradit Chin Med. 2009 Jun;29(2):141-5. doi: 10.1016/s0254-6272(09)60051-0.
OBJECTIVE
To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA).
METHODS
The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA.
RESULTS
The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA.
CONCLUSION
LA has the analgesic and anti-inflammatory effects.
目的
探讨凝胶乌头碱（LA）的镇痛和抗炎作用。
方法
采用乙酸诱导的扭体反应、甲醛诱导的疼痛反应和热板法检测小鼠的疼痛反应，以及蛋清诱导的大鼠足肿胀和二甲苯诱导的小鼠耳肿胀来研究LA的镇痛和抗炎作用。
结果
LA显著抑制了乙酸诱导的扭体反应、甲醛诱导的疼痛反应和热板法检测的疼痛反应。此外，LA还显著抑制了蛋清诱导的大鼠足肿胀和二甲苯诱导的小鼠耳肿胀。
结论
LA具有镇痛和抗炎作用。
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