Tobisu Mamoru, Hyodo Isao, Chatani Naoto
Frontier Research Base for Global Young Researchers, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
J Am Chem Soc. 2009 Sep 2;131(34):12070-1. doi: 10.1021/ja9053509.
The reaction of electron-deficient N-heteroaromatic compounds, such as pyridines and quinolines, with arylzinc reagents in the presence of a catalytic amount of a nickel complex affords the arylated products. The reaction is likely to proceed through a formal nucleophilic 1,2-addition, thus exhibiting a reactivity complementary to conventional direct arylation through electrophilic substitution.
缺电子的氮杂芳族化合物（如吡啶和喹啉）在催化量的镍配合物存在下与芳基锌试剂反应，可得到芳基化产物。该反应可能通过形式上的亲核1,2-加成进行，因此表现出与通过亲电取代的传统直接芳基化互补的反应活性。
