College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea.
Anticancer Agents Med Chem. 2009 Oct;9(8):913-42. doi: 10.2174/187152009789124664.
Naturally occurring cytotoxic compounds have been considered to be a valuable pool of lead compounds in the development of potential anticancer drugs. Currently, some cytotoxic compounds of terrestrial plants are being used as cancer therapeutic drugs and more candidates are under clinical trials along with cytotoxic small molecules of terrestrial microorganisms and marine organisms. In the present review, the structures and representative cytotoxicities of new organic small molecules (over 200 molecules) obtained from terrestrial plants between 2001 and 2004 are presented.
天然存在的细胞毒性化合物被认为是开发潜在抗癌药物的有价值的先导化合物库。目前，一些陆地植物的细胞毒性化合物被用作癌症治疗药物，更多的候选药物正在进行临床试验，同时还有陆地微生物和海洋生物的细胞毒性小分子。在本综述中，介绍了 2001 年至 2004 年期间从陆地植物中获得的新型有机小分子（超过 200 种）的结构和代表性细胞毒性。
