Junker Rüdiger, Dimakis Athanasios, Thoneick Maurice, Jansen John A
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Clin Oral Implants Res. 2009 Sep;20 Suppl 4:185-206. doi: 10.1111/j.1600-0501.2009.01777.x.
The aim of the present review was to evaluate the bone integration efficacy of recently developed and marketed oral implants as well as experimental surface alterations.
A PubMed search was performed for animal studies, human reports and studies presenting bone-to-implant contact percentage or data regarding mechanical testing.
For recently developed and marketed oral implants, 29 publications and for experimental surface alterations 51 publications fulfilled the inclusion criteria for this review.
As demonstrated in the available literature dealing with recently developed and marketed oral implants, surface-roughening procedures also affect the surface chemical composition of oral implants. There is sufficient proof that surface roughening induces a safe and predictable implant-to-bone response, but it is not clear whether this effect is due to the surface roughness or to the related change in the surface composition. The review of the experimental surface alterations revealed that thin calcium phosphate (CaP) coating technology can solve the problems associated with thick CaP coatings, while they still improve implant bone integration compared with non-coated titanium implants. Nevertheless, there is a lack of human studies in which the success rate of thin CaP-coated oral implants is compared with just roughened oral implants. No unequivocal evidence is available that suggests a positive effect on the implant bone integration of peptide sequences or growth factors coated on titanium oral implants. In contrast, the available literature suggests that bone morphogenetic protein-2 coatings might even impede the magnitude of implant-to-bone response.
本综述的目的是评估近期研发并上市的口腔种植体以及实验性表面改性的骨结合效果。
在PubMed上检索动物研究、人体报告以及呈现骨与种植体接触百分比或力学测试数据的研究。
对于近期研发并上市的口腔种植体，29篇出版物符合本综述的纳入标准；对于实验性表面改性，51篇出版物符合纳入标准。
正如有关近期研发并上市的口腔种植体的现有文献所示，表面粗糙化处理也会影响口腔种植体的表面化学成分。有充分证据表明表面粗糙化可诱导安全且可预测的种植体与骨的反应，但尚不清楚这种效果是由于表面粗糙度还是表面成分的相关变化。对实验性表面改性的综述表明，薄磷酸钙（CaP）涂层技术可解决与厚CaP涂层相关的问题，同时与未涂层的钛种植体相比，它们仍能改善种植体与骨的结合。然而，缺乏将薄CaP涂层口腔种植体的成功率与仅表面粗糙化的口腔种植体进行比较的人体研究。没有明确证据表明涂覆在钛口腔种植体上的肽序列或生长因子对种植体与骨的结合有积极作用。相反，现有文献表明骨形态发生蛋白-2涂层甚至可能会阻碍种植体与骨反应的程度。
