Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA.
Prog Neurobiol. 2009 Nov;89(3):231-9. doi: 10.1016/j.pneurobio.2009.07.006. Epub 2009 Aug 5.
Although virtually ignored in the literature until recently, the process of 'stretch growth of integrated axon tracts' is perhaps the most remarkable axon growth mechanism of all. This process can extend axons at seemingly impossible rates without the aid of chemical cues or even growth cones. As animals grow, the organization and extremely rapid expansion of the nervous system appears to be directed purely by mechanical forces on axon tracts. This review provides the first glimpse of the astonishing features of axon tracts undergoing stretch growth and how this natural process can be exploited to facilitate repair of the damaged nervous system.
尽管直到最近在文献中几乎被忽视，但“整合轴突束的拉伸生长”过程也许是所有轴突生长机制中最显著的一种。这个过程可以在没有化学线索甚至生长锥的帮助下，以看似不可能的速度延长轴突。随着动物的生长，神经系统的组织和极其迅速的扩展似乎完全是由轴突束上的机械力来指导的。这篇综述首次揭示了经历拉伸生长的轴突束的惊人特征，以及如何利用这个自然过程来促进受损神经系统的修复。
