丙型肝炎病毒的准种性质及其生物学意义。
The quasispecies nature and biological implications of the hepatitis C virus.
机构信息
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, United States.
出版信息
Infect Genet Evol. 2009 Dec;9(6):1158-67. doi: 10.1016/j.meegid.2009.07.011. Epub 2009 Aug 8.
Abstract
Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus.
摘要
许多 RNA 病毒以一种称为准种的密切相关的序列变异体云的形式存在，而不是作为相同克隆的群体存在。在本文中，我们解释了 RNA 病毒基因组的准种性质，并简要回顾了准种动力学的原理及其与经典群体遗传学的区别。然后，我们讨论了当前的准种分析方法，并以丙型肝炎病毒为例，讨论了这一现象的生物学意义。
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