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本文引用的文献

1
Is single-strand conformation polymorphism analysis of the full 5' untranslated region an adequate approach to study hepatitis C virus quasispecies distribution?对整个5'非翻译区进行单链构象多态性分析，是否是研究丙型肝炎病毒准种分布的合适方法？
J Virol. 2009 Sep;83(17):9018-21. doi: 10.1128/JVI.00971-09. Epub 2009 Jun 24.
2
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.在未经抗逆转录病毒治疗的慢性HIV感染患者中，低丰度耐药病毒变体对治疗结果有显著影响。
J Infect Dis. 2009 Mar 1;199(5):693-701. doi: 10.1086/596736.
3
Review article: investigational agents for chronic hepatitis C.综述文章：慢性丙型肝炎的研究药物。
Aliment Pharmacol Ther. 2009 Apr 1;29(7):689-705. doi: 10.1111/j.1365-2036.2009.03927.x. Epub 2009 Jan 17.
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The population genetics of dN/dS.非同义替换率与同义替换率的群体遗传学
PLoS Genet. 2008 Dec;4(12):e1000304. doi: 10.1371/journal.pgen.1000304. Epub 2008 Dec 12.
5
HCV quasispecies evolution during treatment with interferon alfa-2b and ribavirin in two children coinfected with HCV and HIV-1.两名丙型肝炎病毒（HCV）与人类免疫缺陷病毒1型（HIV-1）合并感染儿童在接受干扰素α-2b和利巴韦林治疗期间的HCV准种演变
J Clin Virol. 2008 Oct;43(2):236-40. doi: 10.1016/j.jcv.2008.06.019. Epub 2008 Aug 15.
6
Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects.初治患者中对NS3.4A蛋白酶抑制剂敏感性降低的丙型肝炎病毒变异体的自然流行率。
J Infect Dis. 2008 Sep 15;198(6):800-7. doi: 10.1086/591141.
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Correlation between pre-treatment quasispecies complexity and treatment outcome in chronic HCV genotype 3a.慢性丙型肝炎病毒3a型患者治疗前准种复杂性与治疗结果的相关性
Virol J. 2008 Jul 9;5:78. doi: 10.1186/1743-422X-5-78.
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Restricted quasispecies variation following infection with the GB virus B.感染GB病毒B后受限的准种变异
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Viral population estimation using pyrosequencing.使用焦磷酸测序法进行病毒群体估计。
PLoS Comput Biol. 2008 May 9;4(4):e1000074. doi: 10.1371/journal.pcbi.1000074.
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Molecular and bioinformatic evidence of hepatitis C virus evolution in brain.丙型肝炎病毒在脑部进化的分子和生物信息学证据。
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丙型肝炎病毒的准种性质及其生物学意义。

The quasispecies nature and biological implications of the hepatitis C virus.

机构信息

Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, United States.

出版信息

Infect Genet Evol. 2009 Dec;9(6):1158-67. doi: 10.1016/j.meegid.2009.07.011. Epub 2009 Aug 8.

DOI:10.1016/j.meegid.2009.07.011
PMID:19666142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2790008/
Abstract

Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus.

摘要

许多 RNA 病毒以一种称为准种的密切相关的序列变异体云的形式存在，而不是作为相同克隆的群体存在。在本文中，我们解释了 RNA 病毒基因组的准种性质，并简要回顾了准种动力学的原理及其与经典群体遗传学的区别。然后，我们讨论了当前的准种分析方法，并以丙型肝炎病毒为例，讨论了这一现象的生物学意义。