Carlberg Carsten, Seuter Sabine
Life Sciences Research Unit, University of Luxembourg, Luxembourg.
Anticancer Res. 2009 Sep;29(9):3485-93.
The vitamin D receptor (VDR) is a ligand-inducible transcription factor whose target genes play key roles in cellular metabolism, bone formation, cellular growth, differentiation and in controlling inflammation. Many of these VDR target genes are also involved in dysregulated pathways leading to common human diseases, such as cancer. The activation of VDR by natural and synthetic ligands may improve such pathological conditions. On a genomic level, these pathways converge on regulatory modules, some of which contain VDR-binding sites, so-called vitamin D response elements (VDREs). Transcriptome analysis, chromatin immunoprecipitation scans and in silico screening approaches have already identified many genomic targets of the VDR. Important cancer regulatory modules with VDREs should have a major impact on understanding the role and potential therapeutic value of VDR in cancer.
维生素D受体（VDR）是一种配体诱导型转录因子，其靶基因在细胞代谢、骨形成、细胞生长、分化以及控制炎症中发挥关键作用。许多这些VDR靶基因也参与导致常见人类疾病（如癌症）的失调途径。天然和合成配体对VDR的激活可能改善此类病理状况。在基因组水平上，这些途径汇聚于调控模块，其中一些包含VDR结合位点，即所谓的维生素D反应元件（VDREs）。转录组分析、染色质免疫沉淀扫描和计算机筛选方法已经确定了VDR的许多基因组靶点。具有VDREs的重要癌症调控模块应该对理解VDR在癌症中的作用和潜在治疗价值产生重大影响。
