Rao Shreyas S, Winter Jessica O
William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University Columbus, OH, USA.
Front Neuroeng. 2009 Jun 9;2:6. doi: 10.3389/neuro.16.006.2009. eCollection 2009.
Adhesion molecules (AMs) represent one class of biomolecules that promote central nervous system regeneration. These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment. Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering. This review discusses common AMs used in neural biomaterials and the mechanism of cell attachment to these AMs. Methods to modify materials with AMs are discussed and compared. Additionally, patterning of AMs for achieving specific neuronal responses is explored.
黏附分子（AMs）是一类促进中枢神经系统再生的生物分子。这些连接分子为再生神经元提供线索，重现天然脑环境。因此，提高非黏附性生物材料的细胞黏附潜力是神经组织工程的一个共同目标。本文综述了神经生物材料中常用的黏附分子以及细胞与这些黏附分子的附着机制。讨论并比较了用黏附分子修饰材料的方法。此外，还探讨了黏附分子的图案化以实现特定的神经元反应。
