Movahedian Bijan, Rismanchian Mansour, Navaei Hooman, Tavanafar Saeid, Koushaei Soheil
Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Prosthodontics, Dental Implants Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Maxillofac Plast Reconstr Surg. 2021 Feb 10;43(1):6. doi: 10.1186/s40902-021-00292-9.
Nicotine can have detrimental effects on dental implant osseointegration. This study aimed to evaluate the influence of systemic L-arginine supplement on the osseointegration of dental implants in nicotine consumer dogs.
Twelve 1-year Labrador Retriever dogs had their right and left third and fourth mandibular premolars removed, and the sockets were left to heal for 6 months. Dogs were randomly divided into three groups (n = 16): group 1-0.2 mg/kg nicotine was injected twice daily; group 2-0.2 mg/kg nicotine was injected twice daily in addition to 200 mg/kg L-arginine capsules taken orally; and group 3-placebo. Forty-eight dental implants were inserted into the healed sockets of the dog's mandible and were assessed by implant stability quotient (ISQ) using resonance frequency analysis (RFA) during 4 weeks and insertion and removal torque value analysis.
No implant failure occurred during the study period. The change in torque value between insertion and removal was similar in the placebo and nicotine+arginine consumer dogs (p = 0.276), which shows a positive effect of arginine supplementation in nicotine consumers. There was a significant difference in torque value change between nicotine+arginine vs. nicotine consumers (p = 0.049) and placebo vs. nicotine (p = 0.003). After 4 weeks, the placebo had the most significant improvement in torque value (47.0 ± 16.9), followed by nicotine+arginine (25.1 ± 37.8), and the worst torque value was for the nicotine group (- 5.7 ± 24.0) pound per inch. The results show that except in the first week, there are significant differences in ISQ between the groups in different periods. ISQ in all of the groups has reduced at first but then increased over time. At the time of implant placement, insertion torque was significantly higher in the nicotine consumer group than the nicotine+arginine consumer group and placebo group (p = 0.020).
Arginine supplementation promotes bone healing and implant primary stability by improving dental implant osseointegration biomechanical characteristics.
尼古丁会对牙种植体的骨整合产生不利影响。本研究旨在评估全身性补充L-精氨酸对尼古丁摄入犬牙种植体骨整合的影响。
12只1岁的拉布拉多猎犬的左右下颌第三和第四前磨牙被拔除，拔牙窝愈合6个月。犬只被随机分为三组（n = 16）：第1组——每天注射两次0.2mg/kg尼古丁；第2组——除每天注射两次0.2mg/kg尼古丁外，还口服200mg/kg L-精氨酸胶囊；第3组——安慰剂组。将48颗牙种植体植入犬下颌愈合的拔牙窝中，并在4周内通过使用共振频率分析（RFA）的种植体稳定性商数（ISQ）以及植入和取出扭矩值分析进行评估。
在研究期间未发生种植体失败。安慰剂组和尼古丁+精氨酸摄入犬组植入和取出之间扭矩值的变化相似（p = 0.276），这表明补充精氨酸对尼古丁摄入者有积极作用。尼古丁+精氨酸组与尼古丁摄入者组之间的扭矩值变化（p = 0.049）以及安慰剂组与尼古丁组之间的扭矩值变化（p = 0.003）存在显著差异。4周后，安慰剂组的扭矩值改善最为显著（47.0±16.9），其次是尼古丁+精氨酸组（25.1±37.8），尼古丁组的扭矩值最差（-5.7±24.0）磅每英寸。结果表明，除第一周外，不同时期各小组之间的ISQ存在显著差异。所有组的ISQ起初均降低，但随后随时间增加。在种植体植入时，尼古丁摄入组的植入扭矩显著高于尼古丁+精氨酸摄入组和安慰剂组（p = 0.020）。
补充精氨酸通过改善牙种植体骨整合的生物力学特性促进骨愈合和种植体初期稳定性。
