通过 NMR 光谱法测定来自荆条的三种新型的诺-新降二萜糖苷化合物荆条苷 A-C 的结构。

Structure determination of chamaedryosides A-C, three novel nor-neo-clerodane glucosides from Teucrium chamaedrys, by NMR spectroscopy.

机构信息

Dipartimento di Scienze della Vita, Laboratorio di Fitochimica, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy.

出版信息

Magn Reson Chem. 2009 Nov;47(11):1007-12. doi: 10.1002/mrc.2499.

DOI:10.1002/mrc.2499

PMID:19670409

Abstract

Three new nor-neo-clerodane diterpenes, named chamaedryoside A (1), B (2) and C (3), have been isolated from the organic extracts of Teucrium chamaedrys (L.) and their structural characterization has been accomplished by (1)H and (13)C-NMR spectra, and DEPT, by COSY, TOCSY, HSQC, HSQC-TOSCY and HMBC experiments, as well as by ESI-MS/MS techniques. The stereostructures have been elucidated by NOESY and computational calculations.

摘要

从荆条（Teucrium chamaedrys（L.））的有机提取物中分离得到三种新的去甲新克列烷二萜，分别命名为 chamaedryoside A（1）、B（2）和 C（3）。通过（1）H 和（13）C-NMR 谱、DEPT、COSY、TOCSY、HSQC、HSQC-TOSCY 和 HMBC 实验以及 ESI-MS/MS 技术对其结构进行了表征。通过 NOESY 和计算计算阐明了立体结构。