Oliveira Naira Elane Moreira de, Cavalcanti Elisa D'Avila Costa, Laport Marinella Silva, Bastos Maria do Carmo de Freire, Giambiagi-deMarval Marcia
Instituto de Microbiologia Prof. Paulo de Góes, Bloco I, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil.
Instituto de Química, Bloco A, Centro de Tecnologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil.
J Med Microbiol. 2009 Dec;58(Pt 12):1582-1584. doi: 10.1099/jmm.0.013912-0. Epub 2009 Aug 13.
Mupirocin is a topical antimicrobial agent that is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). However, the prevalence of mupirocin resistance in S. aureus, particularly in MRSA, has increased. High-level mupirocin resistance, with MICs >or=512 microg ml(-1), is mediated by the ileS-2 gene, which is located on conjugative plasmids. In the present study, we investigated whether mupirocin influences the expression of the ileS-2 gene responsible for high-level mupirocin resistance, and we present some evidence that this gene is not upregulated but constitutively expressed in S. aureus.
莫匹罗星是一种局部用抗菌剂，用于治疗皮肤感染和术后伤口感染，以及预防耐甲氧西林金黄色葡萄球菌（MRSA）的鼻腔携带。然而，金黄色葡萄球菌，尤其是MRSA中莫匹罗星耐药性的发生率有所增加。高水平的莫匹罗星耐药性，MICs≥512μg/ml，由位于接合质粒上的ileS-2基因介导。在本研究中，我们调查了莫匹罗星是否影响负责高水平莫匹罗星耐药性的ileS-2基因的表达，并且我们提供了一些证据表明该基因在金黄色葡萄球菌中不是上调而是组成性表达。
