免疫抑制的肾移植受者体内抗巨细胞病毒诱导早期抗原（CMV-EA）的抗体
Antibodies against cytomegalovirus-induced early antigens (CMV-EA) in immunosuppressed renal-allograft recipients.
作者信息
The T H, Andersen H K, Spencer E S, Klein G
出版信息
Clin Exp Immunol. 1977 Jun;28(3):502-5.
Abstract
Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal implantation all showed CMV-EA antibody rises. Two patients remained seronegative until 4 years after transplantation. Thus, in immunosuppressed patients, antibodies against CMV-EA remained a high titres during many years (4--8 years) after transplantation as distinct from the apparently transient nature in acutely infected previously healthy adults with CMV mononucleosis or post-perfusion syndrome. These results support the view that CMV-EA antibodies reflect an active viral proliferation in the host.
摘要
对15例免疫抑制的肾移植受者的血清进行了抗巨细胞病毒特异性早期抗原（CMV-EA）抗体的跟踪检测。8例患者（62份血清）在移植后47至137天出现血清转化。5例在肾移植时已有CMV抗体的患者（40份血清）均出现CMV-EA抗体升高。2例患者直到移植后4年仍为血清阴性。因此，在免疫抑制患者中，抗CMV-EA抗体在移植后的许多年（4至8年）内保持高滴度，这与先前健康的成年人急性感染CMV单核细胞增多症或灌注后综合征时抗体明显短暂的性质不同。这些结果支持了CMV-EA抗体反映宿主中病毒活跃增殖的观点。
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