Griffiths P D, Buie K J, Heath R B
Arch Virol. 1980;64(4):303-9. doi: 10.1007/BF01320615.
Serial serum samples were obtained from 45 pregnant women who had been shown to possess complement fixing (CF) antibodies to cytomegalovirus (CMV) during a previous pregnancy. The serial samples were tested for antibodies against the early antigens (EA) and complement fixing antigens of CMV. All of the 45 women still possessed CF antibodies at the commencement of their next pregnancy. Six of the 45 women (13 per cent) lacked detectable IFA-EA antibodies whilst 19/45 (42 per cent) women possessed only low titres (less than or equal to 64) of these antibodies. However, 20/45 (44 per cent) women possessed high titre (greater than or equal to 128) antibodies despite having experienced their primary CMV infection many months previously. It is concluded that antibodies to the EA OF CMV are not as transitory as has been suggested and that their presence, even at high titre, in a serum sample from a pregnant woman cannot be taken as presumptive evidence of recent primary infection with this virus.
从45名孕妇身上采集了系列血清样本，这些孕妇在之前的孕期中已被证明拥有针对巨细胞病毒（CMV）的补体结合（CF）抗体。对这些系列样本进行了针对CMV早期抗原（EA）和补体结合抗原的抗体检测。45名女性在下一次怀孕开始时仍拥有CF抗体。45名女性中有6名（13%）缺乏可检测到的免疫荧光法（IFA）-EA抗体，而19/45（42%）的女性仅拥有低滴度（小于或等于64）的这些抗体。然而，20/45（44%）的女性尽管在数月前经历了初次CMV感染，但仍拥有高滴度（大于或等于128）抗体。得出的结论是，针对CMV的EA的抗体并不像所认为的那样短暂，并且在孕妇血清样本中即使存在高滴度的此类抗体，也不能被视为近期初次感染该病毒的推定证据。
