Lau Andy T Y, Chiu Jen-Fu
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.
J Cell Physiol. 2009 Dec;221(3):535-43. doi: 10.1002/jcp.21893.
The lung epithelial surface is one of the vital barriers or sensors in the body responding to the external atmosphere and thereby always subjecting to direct toxicological exposure, stress, stimulus, or infection. Due to its relatively higher sensitivity in response to toxicants, the use of lung epithelial cell culture and lung tissue from animal models or patients has facilitated our learning to lung physiopathology and toxicopharmacology. The recent advancement of proteomics has made it possible to investigate the cellular response at a global level. In this review, the potential applications of proteomic approach in studying lung-related diseases and biomarker discovery will be discussed.
肺上皮表面是人体中对外部大气作出反应的重要屏障或传感器之一，因此总是直接受到毒理学暴露、应激、刺激或感染。由于其对毒物的反应相对较高的敏感性，使用动物模型或患者的肺上皮细胞培养物和肺组织有助于我们了解肺生理病理学和毒理药理学。蛋白质组学的最新进展使在全球范围内研究细胞反应成为可能。在这篇综述中，将讨论蛋白质组学方法在研究肺部相关疾病和发现生物标志物方面的潜在应用。
