Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai Medical College, Shanghai, China.
J Transl Med. 2014 Jan 7;12:6. doi: 10.1186/1479-5876-12-6.
Lymphocytes play important roles in the balance between body defense and noxious agents involved in a number of diseases, e.g. autoimmune diseases, allergic inflammation and cancer. The proteomic analyses have been applied to identify and validate disease-associated and disease-specific biomarkers for therapeutic strategies of diseases. The proteomic profiles of lymphocytes may provide more information to understand their functions and roles in the development of diseases, although proteomic approaches in lymphocytes are still limited. The present review overviewed the proteomics-based studies on lymphocytes to headlight the proteomic profiles of lymphocytes in diseases, such as autoimmune diseases, allergic inflammation and cancer, with a special focus on lung diseases. We will explore the potential significance of diagnostic biomarkers and therapeutic targets from the current status in proteomic studies of lymphocytes and discuss the value of the currently available proteomic methodologies in the lymphocytes research.
淋巴细胞在机体防御与多种疾病相关的有害因子之间的平衡中发挥着重要作用，例如自身免疫性疾病、过敏炎症和癌症。蛋白质组学分析已被应用于鉴定和验证与疾病相关的和疾病特异性的生物标志物，以用于疾病的治疗策略。淋巴细胞的蛋白质组图谱可能提供更多的信息来理解它们在疾病发展中的功能和作用，尽管淋巴细胞的蛋白质组学方法仍然有限。本综述概述了基于蛋白质组学的淋巴细胞研究，以突显淋巴细胞在疾病（如自身免疫性疾病、过敏炎症和癌症）中的蛋白质组图谱，特别关注肺部疾病。我们将从目前的淋巴细胞蛋白质组学研究现状中探讨诊断生物标志物和治疗靶点的潜在意义，并讨论目前可用的蛋白质组学方法在淋巴细胞研究中的价值。
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