Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.
Mutat Res. 2010 Mar 1;685(1-2):45-53. doi: 10.1016/j.mrfmmm.2009.08.002. Epub 2009 Aug 12.
Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.
真核生物基因组的功能取决于两条反向平行 DNA 链的高效和准确复制。真核 DNA 聚合酶具有不同的特性，以适应执行广泛的 DNA 交易。在这里，我们专注于批量复制中的主要参与者，即 B 家族的 DNA 聚合酶。我们从历史的角度回顾了真核生物复制叉的组织，分析了当代模型，并提出了一个新的叉整合模型。
