University of Jena, Faculty of Biology and Pharmacy, Department Food Chemistry, Jena, Germany.
Toxicon. 2010 Oct;56(5):731-8. doi: 10.1016/j.toxicon.2009.07.039. Epub 2009 Aug 11.
Ciguatera fish poisoning characterizes the intoxication caused by consumption of fish from tropical and subtropical areas, which have accumulated ciguatoxins (CTXs). The observed pattern of ciguatoxins in fish highly depends on the marine region and the causative organisms. It is evident that differences exist between ciguatoxins produced by certain strains of the dinoflagellate Gambierdiscus toxicus and other Gambierdiscus spp. In this context cultured strains purchased from the Provasoli-Guillard National Center for Culture of Marine Phytoplankton (CCMP) and strains from Vietnam were analyzed. Besides, lyophilized samples of several Gambierdiscus spp. from the National Oceanic and Atmospheric Administration (NOAA), USA and lyophilized samples of G. toxicus from Vietnam were analyzed. The latter has been cultured at different salinities. We observed differences between the toxin ratios of the analogues in the strain from Vietnam depending on the salinity. The CTX profiles of the Vietnamese samples were compared with cultures of Gambierdiscus spp. from CCMP and the National Oceanic and Atmospheric Administration (NOAA) resulting in an overview of toxins in cultures from different regions. Hence, it was obvious that the strain from Vietnam forms a characteristic CTX profile which is not directly comparable to CTX pattern observed in other tropical marine regions.
雪卡鱼中毒的特征是因食用热带和亚热带地区积累雪卡毒素（CTXs）的鱼类而中毒。鱼体内雪卡毒素的存在模式高度依赖于海洋区域和致病生物体。显然，某些吉氏双鞭毛藻（ Gambierdiscus toxicus ）菌株和其他吉氏双鞭毛藻（ Gambierdiscus spp. ）产生的雪卡毒素存在差异。在这方面，我们分析了从 Provasoli-Guillard 国家海洋浮游植物培养中心（CCMP）购买的培养菌株和来自越南的菌株。此外，还分析了来自美国国家海洋和大气管理局（NOAA）的几种吉氏双鞭毛藻（ Gambierdiscus spp. ）的冻干样本和来自越南的吉氏双鞭毛藻（ Gambierdiscus toxicus ）的冻干样本。后者在不同盐度下进行了培养。我们观察到，越南菌株的类似物的毒素比例因盐度而异。将越南样本的 CTX 图谱与 CCMP 和 NOAA 的 Gambierdiscus spp. 培养物进行比较，得出了来自不同地区培养物中毒素的概述。因此，很明显，来自越南的菌株形成了一种特征性的 CTX 图谱，与在其他热带海洋地区观察到的 CTX 模式无法直接比较。
