表没食子儿茶素没食子酸酯对链脲佐菌素诱导的糖尿病大鼠的慢性降血糖、降血脂作用及抗氧化活性
Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats.
作者信息
Roghani Mehrdad, Baluchnejadmojarad Tourandokht
机构信息
Department of Physiology and Medical Research Center, School of Medicine and Medicinal Plant Research Center, Shahed University, Tehran, Iran.
出版信息
Pathophysiology. 2010 Feb;17(1):55-9. doi: 10.1016/j.pathophys.2009.07.004. Epub 2009 Aug 13.
BACKGROUND AND OBJECTIVE
Green tea catechins including epigallocatechin-3-gallate (EGCG) could exert beneficial health effects to ameliorate metabolic diseases. The effect of chronic administration of EGCG was evaluated on serum glucose and lipid profile and hepatic lipid peroxidation in streptozotocin (STZ)-diabetic rats.
MATERIALS AND METHODS
Rats received EGCG 25mg/kg/day for 8 weeks 1 week after diabetes induction. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels and MDA level and SOD activity in hepatic tissue were spectrophotometrically measured.
RESULTS
Treatment of diabetic rats with EGCG produced a hypoglycemic effect and there were appropriate changes regarding serum lipids in treated diabetic group. Meanwhile, EGCG treatment attenuated the increased MDA content and reduced activity of SOD in liver.
CONCLUSION
Chronic treatment of diabetic rats with EGCG could prevent abnormal changes in blood glucose and lipid profile and attenuat hepatic lipid peroxidation.
背景与目的
绿茶儿茶素，包括表没食子儿茶素没食子酸酯（EGCG），可对改善代谢性疾病产生有益的健康影响。本研究评估了长期给予EGCG对链脲佐菌素（STZ）诱导的糖尿病大鼠血清葡萄糖、脂质谱以及肝脏脂质过氧化的影响。
材料与方法
糖尿病诱导1周后，大鼠连续8周每日接受25mg/kg的EGCG。采用分光光度法测定血清葡萄糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平，以及肝组织中的丙二醛（MDA）水平和超氧化物歧化酶（SOD）活性。
结果
用EGCG治疗糖尿病大鼠产生了降血糖作用，且治疗后的糖尿病组血清脂质有适当变化。同时，EGCG治疗减轻了肝脏中MDA含量的增加，并降低了SOD的活性。
结论
长期用EGCG治疗糖尿病大鼠可预防血糖和脂质谱的异常变化，并减轻肝脏脂质过氧化。
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