Hou Shuyu, Zhou Chunhui, Liu Zhigang, Young Anne W, Shi Zhengshuang, Ren Dacheng, Kallenbach Neville R
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, United States.
Bioorg Med Chem Lett. 2009 Sep 15;19(18):5478-81. doi: 10.1016/j.bmcl.2009.07.077. Epub 2009 Jul 18.
We have investigated the ability of a previously reported antimicrobial peptide dendrimer (RW)(4D) to inactivate Escherichia coli RP437 in planktonic culture and in biofilms. The results show that the dendrimer inhibits bacterial growth in both planktonic and biofilm states. Live/Dead staining assays reveal that most bacteria in a preformed biofilm lose viability after treatment with this peptide. This result is in marked contrast to most existing reports that antimicrobial peptides are ineffective against mature bacterial biofilms.
我们研究了一种先前报道的抗菌肽树枝状聚合物（RW）(4D) 在浮游培养和生物膜中使大肠杆菌RP437失活的能力。结果表明，该树枝状聚合物在浮游和生物膜状态下均能抑制细菌生长。活/死染色分析表明，在用这种肽处理后，预先形成的生物膜中的大多数细菌失去活力。这一结果与大多数现有报道形成鲜明对比，现有报道称抗菌肽对成熟细菌生物膜无效。
