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介孔二氧化硅材料作为药物递送载体：细菌感染的“噩梦”

Mesoporous Silica Materials as Drug Delivery: "The Nightmare" of Bacterial Infection.

作者信息

Martínez-Carmona Marina, Gun'ko Yurii K, Vallet-Regí María

机构信息

School of Chemistry and CRANN, Trinity College, The University of Dublin, Dublin 2, Ireland.

Department Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, Spain.

出版信息

Pharmaceutics. 2018 Dec 15;10(4):279. doi: 10.3390/pharmaceutics10040279.

DOI:10.3390/pharmaceutics10040279
PMID:30558308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6320763/
Abstract

Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the multiple ways of action in which MSM can be used to fight bacterial infection, including early detection, drug release, targeting bacteria or biofilm, antifouling surfaces, and adjuvant capacity. This review focus mainly on those that act as a drug delivery system, and therefore that have an essential characteristic, which is their great loading capacity. Since MSM have advantages in all stages of combatting bacterial infection; its prevention, detection and finally in its treatment, we can venture to talk about them as the "nightmare of bacteria".

摘要

介孔二氧化硅材料（MSM）具有很大的表面积和高孔体积，这意味着它们因此具有很大的负载能力，并且已被证明是治疗包括细菌感染在内的不同病症的独特候选材料。在本文中，我们综述了MSM可用于对抗细菌感染的多种作用方式，包括早期检测、药物释放、靶向细菌或生物膜、防污表面和佐剂能力。本综述主要关注那些作为药物递送系统起作用的方式，因此它们具有一个基本特征，即它们的巨大负载能力。由于MSM在对抗细菌感染的所有阶段（预防、检测以及最终治疗）都具有优势，我们可以大胆地称它们为“细菌的噩梦”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/8e894be52454/pharmaceutics-10-00279-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/2651b34d2b5d/pharmaceutics-10-00279-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/01d8d7d82763/pharmaceutics-10-00279-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/49543cc5016f/pharmaceutics-10-00279-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/85897ab58731/pharmaceutics-10-00279-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/4115e9fd0bbe/pharmaceutics-10-00279-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/bf394761fa6c/pharmaceutics-10-00279-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/538dc6195fef/pharmaceutics-10-00279-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/8e894be52454/pharmaceutics-10-00279-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/2651b34d2b5d/pharmaceutics-10-00279-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/01d8d7d82763/pharmaceutics-10-00279-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/49543cc5016f/pharmaceutics-10-00279-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/7ad52b068007/pharmaceutics-10-00279-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/766d1a442af2/pharmaceutics-10-00279-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/85897ab58731/pharmaceutics-10-00279-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/4115e9fd0bbe/pharmaceutics-10-00279-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/bf394761fa6c/pharmaceutics-10-00279-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/538dc6195fef/pharmaceutics-10-00279-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/6320763/8e894be52454/pharmaceutics-10-00279-g010.jpg

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