Sales M Goreti F, Tomás José F C, Lavandeira Sandra R
CEQUP, Instituto Superior de Engenharia do Porto, Department of Chemical Engineering, Porto, Portugal.
J Pharm Biomed Anal. 2006 Jun 16;41(4):1280-6. doi: 10.1016/j.jpba.2006.03.027. Epub 2006 May 2.
New chlorpromazine selective electrodes with a tubular arrangement and no internal reference solution are proposed. Selective membranes are of poly(vinyl chloride) (PVC) with the tetraphenylborate.chlorpromazine (TPB.CPZ) ion-exchanger dissolved in o-nitrophenyl octyl ether (oNPOE). Analytical features of the electrodes were evaluated on a single-channel flow assembly having 500 microl injection volumes and flow-rates of 4.5 ml min(-1). For a carrier solution of 3.3 x 10(-3)M in sodium sulphate, Nernstian response was observed over the concentration range 1.0 x 10(-5) to 1.0 x 10(-2)M. Average slopes were about 59 mV decade(-1) and squared correlation coefficients were >0.9984. Slight hiper-Nernstian behaviour was observed in buffer solutions of 4.4 pH; average slopes were of 62.06 mV decade(-1). The electrode displayed a good selectivity for CPZ, with respect to, several foreign inorganic and organic species. The selective electrodes were successfully applied to the analysis of pure solutions and pharmaceutical preparations. Proposed method allows the analysis of 84 samples h(-1), producing wastewaters of low toxicity. The proposed method offers the advantage of simplicity, accuracy, applicability to coloured and turbid samples, and automation feasibility.
本文提出了一种新型的管状排列且无内参比溶液的氯丙嗪选择性电极。选择性膜由聚氯乙烯（PVC）制成，其中四苯基硼酸·氯丙嗪（TPB·CPZ）离子交换剂溶解于邻硝基苯基辛醚（oNPOE）中。在进样体积为500微升、流速为4.5毫升/分钟的单通道流动装置上评估了电极的分析特性。对于硫酸钠中浓度为3.3×10⁻³M的载体溶液，在1.0×10⁻⁵至1.0×10⁻²M的浓度范围内观察到能斯特响应。平均斜率约为59毫伏/十倍浓度，平方相关系数>0.9984。在pH为4.4的缓冲溶液中观察到轻微的超能斯特行为；平均斜率为62.06毫伏/十倍浓度。该电极对氯丙嗪表现出良好的选择性，相对于几种外来的无机和有机物种。这些选择性电极已成功应用于纯溶液和药物制剂的分析。所提出的方法允许每小时分析84个样品，产生低毒性的废水。所提出的方法具有简单、准确、适用于有色和浑浊样品以及自动化可行性等优点。
