Wellcome Trust Sanger Institute, Hinxton, The Weatherall Institute of Molecular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Bioinformatics. 2009 Oct 15;25(20):2732-3. doi: 10.1093/bioinformatics/btp488. Epub 2009 Aug 16.
Array-based comparative genomic hybridization (CGH) technology is used to discover and validate genomic structural variation, including copy number variants, insertions, deletions and other structural variants (SVs). The visualization and summarization of the array CGH data outputs, potentially across many samples, is an important process in the identification and analysis of SVs. We have developed a software tool for SV analysis using data from array CGH technologies, which is also amenable to short-read sequence data.
SnoopCGH is written in java and is available from http://snoopcgh.sourceforge.net/
基于阵列的比较基因组杂交 (CGH) 技术用于发现和验证基因组结构变异,包括拷贝数变异、插入、缺失和其他结构变异 (SVs)。对可能来自多个样本的阵列 CGH 数据输出进行可视化和总结是识别和分析 SVs 的重要过程。我们开发了一种使用来自阵列 CGH 技术的数据进行 SV 分析的软件工具,该工具也适用于短读序列数据。
SnoopCGH 是用 Java 编写的,可以从 http://snoopcgh.sourceforge.net/ 获得。