van der Klis F R M, Mollema L, Berbers G A M, de Melker H E, Coutinho R A
Centre for Infectious Disease Control Netherlands, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, the Netherlands.
Neth J Med. 2009 Jul-Aug;67(7):301-8.
In 2006/2007 a large serum bank was established by means of a cross-sectional population-based study. This serum bank will be used to evaluate the Dutch national immunisation programme (NIP) by serosurveillance and additional immunological and epidemiological research. In this paper we describe the design of this population-based cross-sectional serosurvey and report the participation rates as well as general characteristics of the study population. A similar serum bank was collected in 1995/1996. Dutch inhabitants (aged 0-79 years, men and women) were invited from 40 municipalities throughout the country and also from eight additional municipalities known with low vaccination coverage (LVC). An oversampling of the migrant population was performed. Blood samples were obtained from all participants accompanied with extensive information on demographic and epidemiological data, such as vaccination history, risk factors and travelling. In addition, sociodemographic data are available from individuals who declined to participate (non-response survey). Overall 33% of all invitees were included in this study. The serum bank comprises 6386 sera in the nationwide sample including the extra sample of immigrants (n=646) and 1518 sera from the LVC municipalities. The sera will be analysed for antibodies against all NI P antigens but will also be used for other infectious diseases research. Results of this second serosurveillance study will contribute to the discussion whether it is needed to reconsider the schedule and/or the vaccine components of the current National Immunisation Programme.
2006/2007年，通过一项基于人群的横断面研究建立了一个大型血清库。该血清库将用于通过血清学监测以及其他免疫学和流行病学研究来评估荷兰国家免疫规划（NIP）。在本文中，我们描述了这项基于人群的横断面血清学调查的设计，并报告了参与率以及研究人群的一般特征。1995/1996年收集了一个类似的血清库。邀请了来自全国40个城市以及另外8个已知疫苗接种覆盖率低（LVC）的城市的荷兰居民（年龄在0 - 79岁之间，男女不限）。对移民人口进行了过度抽样。从所有参与者那里采集了血样，并附带了有关人口统计学和流行病学数据的广泛信息，如疫苗接种史、风险因素和旅行情况。此外，对于拒绝参与的个体（无应答调查）也可获得社会人口统计学数据。总体而言，所有被邀请者中有33%被纳入了本研究。血清库在全国样本中包含6386份血清，包括移民的额外样本（n = 646）以及来自LVC城市的1518份血清。这些血清将被分析针对所有NIP抗原的抗体，但也将用于其他传染病研究。这项第二次血清学监测研究的结果将有助于讨论是否需要重新考虑当前国家免疫规划的时间表和/或疫苗成分。
