Sergeant Gregory, Vankelecom Hugo, Gremeaux Lies, Topal Baki
Department of Surgery, Catholic University of Leuven, Leuven, Belgium.
Nat Rev Clin Oncol. 2009 Oct;6(10):580-6. doi: 10.1038/nrclinonc.2009.127. Epub 2009 Aug 18.
As our understanding of pancreatic cancer evolves, evidence is growing to support a role for cancer stem cells in this devastating disease. Cancer stem cells constitute a distinct subpopulation in the tumor and are considered to drive both tumorigenesis and metastasis; these cells are thought to be highly resistant to standard treatment modalities. Here we review the current knowledge on pancreatic cancer stem cells and the implementation of cancer stem cell markers as prognostic or predictive biomarkers. We also discuss prospects for the use of cancer stem cells as targets for future therapeutic regimens in pancreatic cancer.
随着我们对胰腺癌认识的不断发展，越来越多的证据支持癌症干细胞在这种毁灭性疾病中发挥作用。癌症干细胞在肿瘤中构成一个独特的亚群，被认为驱动肿瘤发生和转移；这些细胞被认为对标准治疗方式具有高度抗性。在此，我们综述了目前关于胰腺癌干细胞的知识以及癌症干细胞标志物作为预后或预测生物标志物的应用。我们还讨论了将癌症干细胞作为未来胰腺癌治疗方案靶点的前景。
