利用空间调制结构光进行亚表面不均匀性的定量光学层析成像。
Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light.
作者信息
Konecky Soren D, Mazhar Amaan, Cuccia David, Durkin Anthony J, Schotland John C, Tromberg Bruce J
机构信息
Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute, University of California - Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA.
出版信息
Opt Express. 2009 Aug 17;17(17):14780-90. doi: 10.1364/oe.17.014780.
Abstract
We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.
摘要
我们提出了一种用于获取混浊介质三维图像的宽场方法。通过将具有不同空间频率的光图案投射到样品上，我们重建了吸收对比度的定量、深度分辨图像。使用快速解析反演公式和对扩散近似的一种新颖校正来重建图像，以提高边界附近的精度。该方法比标准漫反射测量提供了更准确的光吸收定量和更高的分辨率。
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