Jiang Yingfeng, Zhang Jing, Liu Yuan, Huang Ting, Cao Zheng, Shi Xiangkui
Department of Pharmacy, Xuzhou Maternity and Child Health Care Hospital, Xuzhou 221009, P.R. China.
Iran J Public Health. 2021 Jan;50(1):139-145. doi: 10.18502/ijph.v50i1.5080.
The difference in serum 25-hydroxyvitamin D (25-(OH) D ) level between the gestational diabetes mellitus (GDM) and healthy pregnant women was analyzed, to provide the experimental evidence for the vitamin supplement in pregnant women, especially those with GDM.
Pregnant women (n=50) who received prenatal care in the Obstetrical Clinic of Xuzhou Maternity and Child Health Care Hospital in summer and winter of 2016 were enrolled. They were assigned to the summer GDM group, winter GDM group, summer control group and winter control group. The level of serum 25-(OH)D was determined using immunochromatography.
The mean level of serum 25-(OH)D in pregnant women of four groups was lower than normal level. Compared with control group in corresponding season, the winter and summer GDM groups had significantly lower level of 25-(OH)D than the winter and summer control groups (<0.05). The winter GDM group had significantly lower level of 25-(OH)D than the summer GDM group (<0.05). The winter control group had significantly lower level of 25-(OH)D than the summer control group (<0.05). The percentage of deficient 25-(OH)D level was the highest in winter GDM group. Vitamin D deficiency was severer in pregnant women with GDM than healthy pregnant women. In winter, vitamin D deficiency was severer than that in summer.
Pregnant women, especially those with GDM, should pay more attention to vitamin D supplementation.
分析妊娠期糖尿病（GDM）孕妇与健康孕妇血清25-羟维生素D（25-(OH)D）水平的差异，为孕妇尤其是GDM孕妇补充维生素提供实验依据。
选取2016年夏冬两季在徐州市妇幼保健院产科门诊接受产前检查的孕妇（n = 50）。将其分为夏季GDM组、冬季GDM组、夏季对照组和冬季对照组。采用免疫层析法测定血清25-(OH)D水平。
四组孕妇血清25-(OH)D的平均水平均低于正常水平。与相应季节的对照组相比，冬季和夏季GDM组的25-(OH)D水平显著低于冬季和夏季对照组（P<0.05）。冬季GDM组的25-(OH)D水平显著低于夏季GDM组（P<0.05）。冬季对照组的25-(OH)D水平显著低于夏季对照组（P<0.05）。25-(OH)D水平缺乏的比例在冬季GDM组中最高。GDM孕妇的维生素D缺乏情况比健康孕妇更严重。在冬季，维生素D缺乏情况比夏季更严重。
孕妇尤其是GDM孕妇应更加重视补充维生素D。
