Celik Atilla, Altinli Ediz, Koksal Neset, Celik Aysun Simsek, Onur Ender, Ozkan Omer Faruk, Gumrukcu Gulistan
Second Department of General Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Surg Laparosc Endosc Percutan Tech. 2009 Aug;19(4):e130-4. doi: 10.1097/SLE.0b013e3181aa598d.
The aim of our study was to determine and compare the shrinking rates of different prosthetic materials used in ventral hernia repair and to establish a possible correlation with macroscopic adhesions, histopathologic inflammation, and fibrosis.
Thirty-six Wistar albino rats were divided into 4 groups (T, V, S, and D). A midline laparotomy was performed under general anesthesia. A 30x40 mm-sized mesh was placed intraperitoneally and fixed with an interrupted 4/0 polypropylene suture to the anterior abdominal wall. In group T, TiMesh; group V, Vypro II; group S, Sepramesh; and group D, DynaMesh-IPOM were used. All rats were killed at the 90th day postoperatively and the mesh area and the shrinking rate were calculated. Each group was evaluated in correlation with shrinking, adhesion, histopathologic inflammation, and fibrosis, and compared with each other.
The mean area was 1013.33 mm2 in the T group, 930.44 mm2 in the V group, 1024.44 mm2 in the S group, and 1073.8 mm2 in the D group. The shrinking areas were found as 186.67 mm2, 269.55 mm2, 177.55 mm2, and 126.2 mm2, respectively. The shrinking rates were statistically significant in each group. The lowest shrinking rate was found in group D and highest in group V, but the results were statistically insignificant. In terms of macroscopic adhesion, histopathologic inflammation, and fibrosis no statistically significant differences were found among all the groups in comparison with each other.
Although the shrinking rate of DynaMesh is lowest among all the groups, the results are statistically insignificant. The results of our experimental study revealed no superiority in the means of mesh shrinkage among TiMesh, Vypro II, Sepramesh, and DynaMesh in the rats.
本研究旨在测定并比较腹疝修补术中使用的不同修复材料的收缩率，并确定其与宏观粘连、组织病理学炎症和纤维化之间可能存在的相关性。
将36只Wistar白化大鼠分为4组（T组、V组、S组和D组）。在全身麻醉下进行正中剖腹术。将一块30×40mm大小的补片置于腹腔内，并用4/0聚丙烯间断缝线固定于前腹壁。T组使用TiMesh；V组使用Vypro II；S组使用Sepramesh；D组使用DynaMesh-IPOM。所有大鼠在术后第90天处死，计算补片面积及收缩率。对每组进行收缩、粘连、组织病理学炎症和纤维化方面的评估，并相互比较。
T组平均面积为1013.33mm²，V组为930.44mm²，S组为1024.44mm²，D组为1073.8mm²。收缩面积分别为186.67mm²、269.55mm²、177.55mm²和126.2mm²。每组的收缩率均具有统计学意义。收缩率最低的是D组，最高的是V组，但结果无统计学意义。在宏观粘连、组织病理学炎症和纤维化方面，各组之间相互比较未发现统计学上的显著差异。
尽管DynaMesh在所有组中收缩率最低，但结果无统计学意义。我们的实验研究结果表明，在大鼠中，TiMesh、Vypro II、Sepramesh和DynaMesh在补片收缩方面并无优势。
