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从白细胞介素-10到白细胞介素-12：病原体及其产物如何刺激抗原呈递细胞诱导辅助性T细胞1型分化。

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development.

作者信息

O'Garra Anne, Murphy Kenneth M

机构信息

Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK.

出版信息

Nat Immunol. 2009 Sep;10(9):929-32. doi: 10.1038/ni0909-929.

DOI:10.1038/ni0909-929
PMID:19692989
Abstract

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

摘要

作者讲述了他们对病原体诱导白细胞介素12产生如何导致辅助性T细胞1（TH1）极化的发现。同时，他们发现抑制性细胞因子白细胞介素10可抑制抗原呈递细胞，从而调节TH1细胞的发育。

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