[左旋肉碱改善奥硝唑诱导的雄性大鼠弱精子症的生殖功能]
[L-carnitine improves the reproductive function of male rats with ornidazole-induced asthenospermia].
作者信息
Zhang Wen, Liu Qing-Zhen, Shang Xue-Jun, Huang Yu-Feng, Wang Hao-Yang
机构信息
Department of Family Planning, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
出版信息
Zhonghua Nan Ke Xue. 2009 Jul;15(7):604-7.
OBJECTIVE
To explore the protective effect of L-carnitine (LC) on the reproductive function of male rats with asthenospermia induced by ornidazole (ORN).
METHODS
Forty male SD rats (200-230 g) were randomly divided into Groups A (control: 0.5% carboxymethylcellulose solution), B (medium-dose ORN: 400 mg/kg/d), C (medium-dose ORN + LC: ORN 400 mg/kg/d + LC 100 mg/kg/d), D (high-dose ORN: 800 mg/kg/d), and E (high-dose ORN + LC: ORN 800 mg/kg/d + LC 100 mg/kg/d). All the rats were treated via gastric gavage for 20 days consecutively, and then killed for the detection of sperm motility and the sperm count of the cauda epididymis.
RESULTS
Compared with Group A, there was a significant decrease in sperm motility and sperm count in Groups B and D (P < 0.05), while Group C showed a significant increase in both the parameters as compared with B (P < 0.05), but with no significant difference from A (P > 0.05). Group E exhibited no obvious improvement in sperm motility and sperm count, with no difference from D (P > 0.05).
CONCLUSION
L-carnitine can improve the sperm motility and sperm count of the male rats with ornidazole-induced asthenospermia.
目的
探讨左旋肉碱（LC）对奥硝唑（ORN）诱导的弱精子症雄性大鼠生殖功能的保护作用。
方法
将40只体重200 - 230 g的雄性SD大鼠随机分为A组（对照组：0.5%羧甲基纤维素溶液）、B组（中剂量ORN组：400 mg/kg/d）、C组（中剂量ORN + LC组：ORN 400 mg/kg/d + LC 100 mg/kg/d）、D组（高剂量ORN组：800 mg/kg/d）和E组（高剂量ORN + LC组：ORN 800 mg/kg/d + LC 100 mg/kg/d）。所有大鼠连续灌胃给药20天，然后处死，检测附睾尾精子活力和精子计数。
结果
与A组相比，B组和D组精子活力和精子计数显著降低（P < 0.05），而C组与B组相比，这两项参数均显著升高（P < 0.05），但与A组无显著差异（P > 0.05）。E组精子活力和精子计数无明显改善，与D组无差异（P > 0.05）。
结论
左旋肉碱可提高奥硝唑诱导的弱精子症雄性大鼠的精子活力和精子计数。
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