Pian Jerry P, Criado Jose R, Walker Brendan M, Ehlers Cindy L
Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA.
Pharmacol Biochem Behav. 2009 Nov;94(1):179-85. doi: 10.1016/j.pbb.2009.08.006. Epub 2009 Aug 19.
Early onset of alcohol consumption increases the risk for the development of dependence. Whether adolescent consumption of other highly palatable solutions may also affect alcohol drinking in adulthood is not known. The purpose of this study was to determine the effects of adolescent consumption of four solutions: water, sucrose, sucrose-milk and milk on ethanol drinking in adult rats. Rats had limited access to one of the four solutions from day PND 29 to PND 51 and were subsequently trained to consume ethanol (E) using a sucrose (S) fade-out procedure. Adolescent consumption of sucrose and sucrose-milk solutions increased intake of 2.5% E when it was combined with 10% S but it had no effect on the drinking of 10% E alone. Adolescent consumption of milk and sucrose-milk significantly decreased the intake of 10% E when it was combined with 10% S, and milk significantly reduced 10% E consumption alone and when it was combined with 5% S. Adolescent exposure to the sucrose-milk and sucrose solutions was also found to increase sucrose and sucrose-milk consumption. Our findings suggest adolescent exposure to sucrose increases, whereas, exposure to milk reduces ethanol consumption in adult rats. Our results may provide a new theoretical approach to the early prevention of alcoholism.
过早开始饮酒会增加产生酒精依赖的风险。青少年饮用其他高度可口的溶液是否也会影响成年后的饮酒情况尚不清楚。本研究的目的是确定青少年饮用四种溶液（水、蔗糖、蔗糖 - 牛奶和牛奶）对成年大鼠乙醇饮用的影响。从出生后第29天到第51天，大鼠只能有限地接触这四种溶液中的一种，随后使用蔗糖淡出程序训练它们饮用乙醇（E）。青少年饮用蔗糖和蔗糖 - 牛奶溶液会增加2.5%乙醇与10%蔗糖混合时的摄入量，但对单独饮用10%乙醇没有影响。青少年饮用牛奶和蔗糖 - 牛奶会显著降低10%乙醇与10%蔗糖混合时的摄入量，并且牛奶单独饮用以及与5%蔗糖混合时都会显著降低10%乙醇的摄入量。还发现青少年接触蔗糖 - 牛奶和蔗糖溶液会增加蔗糖和蔗糖 - 牛奶的摄入量。我们的研究结果表明，青少年接触蔗糖会增加成年大鼠的乙醇摄入量，而接触牛奶则会减少乙醇摄入量。我们的结果可能为酒精中毒的早期预防提供一种新的理论方法。
