INSERM ERI17, Laboratoire HP2, Université Joseph Fourier, Faculté de Médecine, Grenoble, France.
PLoS One. 2009 Aug 24;4(8):e6733. doi: 10.1371/journal.pone.0006733.
Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic hypoventilation adds to obesity on systemic inflammation and endothelial dysfunction remains unknown.
To compare inflammatory status and endothelial function in OHS versus eucapnic obese patients.
14 OHS and 39 eucapnic obese patients matched for BMI and age were compared. Diurnal blood gazes, overnight polysomnography and endothelial function, measured by reactive hyperemia peripheral arterial tonometry (RH-PAT), were assessed. Inflammatory (Leptin, RANTES, MCP-1, IL-6, IL-8, TNFalpha, Resistin) and anti-inflammatory (adiponectin, IL-1Ra) cytokines were measured by multiplex beads immunoassays.
OHS exhibited a higher PaCO(2), a lower forced vital capacity (FVC) and tended to have a lower PaO(2) than eucapnic obese patients. (HS)-CRP, RANTES levels and glycated haemoglobin (HbA1c) were significantly increased in OHS (respectively 11.1+/-10.9 vs. 5.7+/-5.5 mg x l(-1) for (HS)-CRP, 55.9+/-55.3 vs 23.3+/-15.8 ng/ml for RANTES and 7.3+/-4.3 vs 6.1+/-1.7 for HbA1c). Serum adiponectin was reduced in OHS (7606+/-2977 vs 13,660+/-7854 ng/ml). Endothelial function was significantly more impaired in OHS (RH-PAT index: 0.22+/-0.06 vs 0.51+/-0.11).
Compared to eucapnic obesity, OHS is associated with a specific increase in the pro-atherosclerotic RANTES chemokine, a decrease in the anti-inflammatory adipokine adiponectin and impaired endothelial function. These three conditions are known to be strongly associated with an increased cardiovascular risk.
ClinicalTrials.gov NCT00603096.
肥胖低通气综合征（OHS）与心血管发病率增加有关。中度慢性低通气对肥胖患者的系统性炎症和内皮功能的影响尚不清楚。
比较 OHS 与正常通气肥胖患者的炎症状态和内皮功能。
比较了 14 例 OHS 和 39 例匹配 BMI 和年龄的正常通气肥胖患者。评估了日间血气、整夜多导睡眠图和内皮功能，通过反应性充血外周动脉张力测量法（RH-PAT）进行测量。通过多重珠免疫分析测量了炎症（瘦素、RANTES、MCP-1、IL-6、IL-8、TNFalpha、Resistin）和抗炎（脂联素、IL-1Ra）细胞因子。
OHS 患者的 PaCO2 较高，用力肺活量（FVC）较低，PaO2 趋势较低。与正常通气肥胖患者相比，OHS 患者的（hs）-CRP、RANTES 水平和糖化血红蛋白（HbA1c）显著升高（分别为 11.1+/-10.9 与 5.7+/-5.5mg x l(-1) 用于（hs）-CRP，55.9+/-55.3 与 23.3+/-15.8ng/ml 用于 RANTES，7.3+/-4.3 与 6.1+/-1.7 用于 HbA1c）。血清脂联素在 OHS 中减少（7606+/-2977 与 13660+/-7854ng/ml）。与正常通气肥胖患者相比，OHS 患者的内皮功能明显受损（RH-PAT 指数：0.22+/-0.06 与 0.51+/-0.11）。
与正常通气肥胖相比，OHS 与动脉粥样硬化前趋化因子 RANTES 的特异性增加、抗炎脂联素的减少和内皮功能受损有关。这三种情况与心血管风险增加密切相关。
ClinicalTrials.gov NCT00603096。
