Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 19395-4763, Tehran, Iran.
Eur J Epidemiol. 2010;25(1):45-53. doi: 10.1007/s10654-009-9382-3. Epub 2009 Aug 22.
This study was performed to determine the risk factor pattern of the metabolic syndrome (MetS) in association with serum nitric oxide metabolites (NO(x)) in children and adolescents. The study included 851 children and adolescents, aged 4-19 years. The MetS was defined according to modified Adult treatment Panel III criteria. Cluster analysis was performed using principle components analysis with varimax orthogonal rotation to examine the risk factor pattern of the MetS. The prevalence of MetS was 10.8 and 10.0% in males and females, respectively. Age-and sex-adjusted odds ratio of having MetS was significantly higher in the upper quartile of NO(x) compared to the lower quartile (2.2, 95% CI: 1.1-4.7, p = 0.029). In the whole population, three factors were identified including blood pressure/obesity, lipid/obesity, and glucose/NO(x). Stratifying for sex, again three factors were retained; however, in males NO(x) was loaded in two factors. In conclusion, serum NO( x ) was associated and loaded with other MetS components in cluster analysis of metabolic risk factors.
本研究旨在确定儿童和青少年代谢综合征（MetS）与血清一氧化氮代谢物（NO(x)）之间的风险因素模式。该研究纳入了 851 名 4-19 岁的儿童和青少年。MetS 根据改良成人治疗小组 III 标准定义。采用主成分分析和方差极大正交旋转进行聚类分析，以检查 MetS 的风险因素模式。男性和女性 MetS 的患病率分别为 10.8%和 10.0%。与下四分位数相比，NO(x)上四分位数的 MetS 发生比值比（OR）具有显著的年龄和性别调整（2.2，95%CI：1.1-4.7，p=0.029）。在整个人群中，确定了包括血压/肥胖、血脂/肥胖和血糖/NO(x)在内的三个因素。按性别分层，再次保留了三个因素；然而，在男性中，NO(x)被加载到两个因素中。总之，血清 NO(x)与代谢风险因素聚类分析中的其他 MetS 成分相关并被其加载。
