内毒素、D-乳酸和二胺氧化酶与炎症性肠病内镜活动的相关性。
The Correlation between Endotoxin, D-Lactate, and Diamine Oxidase with Endoscopic Activity in Inflammatory Bowel Disease.
机构信息
Department of General Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
出版信息
Dis Markers. 2022 Sep 16;2022:9171436. doi: 10.1155/2022/9171436. eCollection 2022.
METHODS
A total of 149 eligible IBD patients including 82 Crohn disease (CD) and 67 Ulcerative colitis (UC) who had received both endoscopic examination and intestinal barrier function detection in our hospital were enrolled in this study. Endoscopic activity was estimated by the Simple Endoscopic Score (SES-CD) for Crohn's Disease and the ulcerative colitis endoscopic index of severity (UCEIS) for ulcerative colitis. The predictive value and optimal predictive thresholds for those biomarkers were determined by receiver operating characteristic analysis.
RESULTS
For UC patients, DAO, D-lactate, and ETX showed better correlation with UCEIS than erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and exhibited satisfactory predictive value in predicting remission. Among patients with CD, DAO and ETX not only showed a better correlation than WBC, ESR, and CRP with SES-CD but also capable to identify more severe patients.
CONCLUSION
DAO and ETX could be used to distinguish different endoscopic activity of CD. DAO, D-lactate, and ETX could predict UC endoscopic remission.
方法
本研究共纳入 149 例符合条件的 IBD 患者，包括 82 例克罗恩病（CD）和 67 例溃疡性结肠炎（UC），这些患者均在我院接受了内镜检查和肠道屏障功能检测。采用克罗恩病简单内镜评分（SES-CD）和溃疡性结肠炎内镜严重指数（UCEIS）评估内镜活动度。通过受试者工作特征分析确定这些生物标志物的预测价值和最佳预测阈值。
结果
对于 UC 患者，DAO、D-乳酸和 ETX 与 UCEIS 的相关性优于红细胞沉降率（ESR）和 C 反应蛋白（CRP），并具有良好的预测缓解的价值。在 CD 患者中，DAO 和 ETX 不仅与白细胞计数（WBC）、ESR 和 CRP 相比与 SES-CD 相关性更好，而且能够识别更严重的患者。
结论
DAO 和 ETX 可用于区分 CD 的不同内镜活动度。DAO、D-乳酸和 ETX 可预测 UC 的内镜缓解。
Zotero 插件