Wolf A R, Hughes D, Wade A, Mather S J, Prys-Roberts C
Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol Royal Hospital for Sick Children.
Br J Anaesth. 1990 Apr;64(4):430-5. doi: 10.1093/bja/64.4.430.
The value of combining morphine with bupivacaine for caudal analgesia was investigated. Thirty children, undergoing orchidopexy, received a caudal block of 0.125% bupivacaine with or without morphine 0.05 mg kg-1. Analgesia, side-effects, ventilatory frequency and oxygen saturation (SaO2) were recorded after operation. None of the 15 patients receiving the bupivacaine-morphine mixture required post-operative opioids, whereas eight of 15 patients receiving bupivacaine alone needed additional opioid analgesia. The incidence of side effects after surgery was similar for the two groups and there was no detectable difference in ventilatory frequency or SaO2.
研究了吗啡与布比卡因联合用于骶管镇痛的价值。30例接受睾丸固定术的儿童接受了0.125%布比卡因的骶管阻滞，其中部分儿童还加入了0.05 mg/kg的吗啡。记录术后的镇痛效果、副作用、呼吸频率和血氧饱和度（SaO2）。接受布比卡因-吗啡混合液的15例患者中无一例术后需要使用阿片类药物，而单独接受布比卡因的15例患者中有8例需要额外的阿片类镇痛。两组术后副作用的发生率相似，呼吸频率或SaO2没有可检测到的差异。
